The immobilization of chelators to solid supports has recently gained renewed interest due to the increasing biomedical and environmental applications made possible by these molecules’ ability to bind Fe(III) and other metal ions. The uses of immobilized chelators have expanded to include the treatment of metal overload in serum, the...
The Jovanovic lab at Oregon State University (OSU) is developing iCore, a versatile blood processing platform which leverages microfluidic process intensification via increased mass transfer efficiency and decreased device footprint with the goal of creating a portable, wearable device. One application of iCore is for the treatment of hyperferremia resulting...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
Solvent extraction is an integral chemical and biochemical separation process that is drastically intensified in microfluidic systems. A novel high-throughput micro-separator was additively manufactured for the intensification of liquid–liquid separation. The micro-posts array within the flow plate generated a capillary pressure gradient on the non-wetting organic phase, enabling continuous, membrane-free,...
Microscale-based technology has potential applications in the medical field. The development of a new microscale medical device requires experimentation and testing. This can be done by creating a breadboard device that can perform the functionalities the final device should be able to do. This breadboard device can also be used...
Advances in plant construction within the energy and chemical process industries require inexpensive process intensification (PI) technology as a means to reduce plant size for enabling modular construction. One form of PI is microchannel process technology where arrays of microchannels, having hydraulic diameters on the order of 0.1 to 1...
Exergy relates to thermodynamic value or usefulness in the universe. In this dissertation, three methods in the realm of "process intensification" are explored to reduce exergy destruction by equipment and processes that are used to convert and upgrade methane. Thermodynamic efficiency of a virtual heat exchanger is improved with a...