Graduate Thesis Or Dissertation
 

Cephalic phase insulin release : the role of oral glucose detection and its measurement in humans

Public Deposited

Downloadable Content

Download PDF
https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/73666d51w

Descriptions

Attribute NameValues
Creator
Abstract
  • Sensory stimulation from food-related cues elicits a number of rapid physiologic responses that prepare the gastrointestinal tract for efficient nutrient utilization and help minimize perturbations to metabolic homeostasis. Cephalic phase insulin release (CPIR) is one such response that specifically promotes glucose homeostasis by limiting the rise in blood sugar after a meal. While the exact mechanisms responsible for eliciting CPIR have not been defined, stimulation of the gustatory (taste) system, especially with glucose-containing carbohydrates, appears to be particularly effective for inducing the response. However, it is unclear if this is due to the system detecting glucose itself, or to the conscious perception of taste cues associated with carbohydrates (i.e., sweet and starchy). Understanding the specific mechanisms by which gustatory carbohydrate sensing stimulates this response will be a fundamental step in CPIR research: it will allow for more focused investigations into the physiological and clinical implications of CPIR and, in parallel, will be integral for defining the properties required for foods and therapeutic agents designed to promote CPIR in an effort to support human health. The overall goal of this work was to achieve a better understanding of how carbohydrates stimulate CPIR in humans by investigating factors related to the oral detection of glucose and glucose-based saccharides.
License
Resource Type
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Academic Affiliation
Rights Statement
Publisher
Peer Reviewed
Language
Embargo reason
  • Pending Publication
Embargo date range
  • 2023-06-09 to 2024-01-11

Relationships

Parents:

This work has no parents.

In Collection:

Items

Thumbnail Title Date Uploaded Visibility Actions
file details PullicinAlexaJ2023.pdf 2023-06-14 Public Download