Graduate Thesis Or Dissertation
 

Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/g445cn59c

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  • The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available for researchers who investigate phenomena related to the behavior of the ECM in disease. However, in the context of gynecological diseases, such as gynecological cancer and endometriosis, matrisome gene expression dynamics remain underexplored. Additionally, while numerous computational methods have been applied to, or specifically developed for, analyzing gene expression data, a standardized analysis pipeline has not been adopted. Thus, the objective of the work presented here was to better elucidate changes to the matrisome during disease onset and progression. This was achieved by developing a modular analysis pipeline that can be used to explore matrisome dysregulation in disease tissue, linking matrisome gene and gene network expression with disease progression and patient outcome. In the following chapters, we employ this pipeline to explore the expression of matrisome genes in gynecological cancers and endometriosis. The results of this work can be used for future studies to evaluate matrisome genes and gene networks as potential drug targets or incorporated into in vitro models of disease.
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