Interactions between the immune system, stress and thymulin Public Deposited

http://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/k0698981w

Descriptions

Attribute NameValues
Creator
Abstract or Summary
  • This study was conducted to determine the effects of shipping stress on the immune system in domestic lambs (Ovis aries) and to determine the potential of the thymic peptide, thymulin, to reduce those effects of stress on the immune system. Treatments consisted of no shipping (as unstressed controls), shipping (as stressed controls) or shipping plus two doses of thymulin. The shipping procedure was conducted for two consecutive days. The responses were measured in three ways. First, the ability of peripheral blood mononuclear cells (PBMN) to respond to four different doses of the mitogen, Interleukin-2 (IL-2), was measured. Second, antibody response to a standard antigen dose over a three week period following the stress was examined. Third, the plasma cortisol concentrations in stressed versus unstressed and in thymulin treated lambs were compared. There were no differences between any of the four treatment groups (p>0.44) with respect to the animals' lymphocyte proliferative ability. Although there were no detectable differences, caution should be used in interpreting these results, because of technical difficulties encountered with a key reagent in the assay. Antibody titers were measured at weekly intervals for each of three consecutive weeks following the stressing procedure. These results also showed no treatment effect between any of the four groups (p>0.39). A comparison of cortisol levels in the four groups revealed that shipping stress increased plasma cortisol concentrations, and thymulin treatment at either dose and on both days of shipment inhibited (p<0.0001 and p<0.047, for day one and two, respectively) that stress-induced increase in cortisol. Interestingly, these results indicate that treatment with thymulin was effective in negating the stress-associated increase in plasma cortisol levels in the lambs. These in vivo data support a possible immunomodulatory function of thymulin.
Resource Type
Date Available
Date Copyright
Date Issued
Degree Level
Degree Name
Degree Field
Degree Grantor
Commencement Year
Advisor
Committee Member
Academic Affiliation
Non-Academic Affiliation
Subject
Rights Statement
Peer Reviewed
Language
Digitization Specifications
  • File scanned at 300 ppi (Monochrome, 8-bit Grayscale) using ScandAll PRO 1.8.1 on a Fi-6670 in PDF format. CVista PdfCompressor 4.0 was used for pdf compression and textual OCR.
Replaces
Additional Information
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-10-09T17:57:45Z (GMT) No. of bitstreams: 1 ChristianRichardL1997.pdf: 3524616 bytes, checksum: 2a86e1b361ce5da53ef35348456799fc (MD5)
  • description.provenance : Made available in DSpace on 2012-10-09T17:59:39Z (GMT). No. of bitstreams: 1 ChristianRichardL1997.pdf: 3524616 bytes, checksum: 2a86e1b361ce5da53ef35348456799fc (MD5) Previous issue date: 1997-03-04
  • description.provenance : Approved for entry into archive by Patricia Black(patricia.black@oregonstate.edu) on 2012-10-09T17:59:39Z (GMT) No. of bitstreams: 1 ChristianRichardL1997.pdf: 3524616 bytes, checksum: 2a86e1b361ce5da53ef35348456799fc (MD5)
  • description.provenance : Submitted by John Valentino (valentjo@onid.orst.edu) on 2012-10-08T23:13:43Z No. of bitstreams: 1 ChristianRichardL1997.pdf: 3524616 bytes, checksum: 2a86e1b361ce5da53ef35348456799fc (MD5)

Relationships

In Administrative Set:
Last modified: 08/03/2017

Downloadable Content

Download PDF
Citations:

EndNote | Zotero | Mendeley

Items