Graduate Thesis Or Dissertation
 

Canine LH Receptors Expression in Non-neoplastic and Neoplastic Tissues

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https://ir.library.oregonstate.edu/concern/graduate_thesis_or_dissertations/p2676z95s

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  • Throughout most of the developed world, surgical sterilization via gonadectomy has become a common tool for combating the overpopulation of unwanted dogs as well as to eliminate the risk of reproductive diseases in pet dogs. In the dog as in other normal adult mammal, the hypothalamus secretes gonadotropin-releasing hormone (GnRH), which stimulates the anterior pituitary gland to release luteinizing hormone. Luteinizing hormone (LH) stimulates the secretion of gonadal steroid hormones (testosterone in males and estrogen/progesterone in females). These gonadal steroid hormones then negatively feedback to the hypothalamus and anterior pituitary to decrease the secretion of GnRH and LH, respectively. However, in the gonadectomized mammal, there is no negative feedback, which results in supraphysiologic circulating concentrations of LH. In gonadectomized dogs, LH concentrations are more than thirty times the concentrations found in normal adult dogs. Although the main role of LH is for reproductive functions (e.g. ovulation, corpus luteum formation), there are LH receptors present throughout the body, not just limited to the reproductive tract. The purpose of LH receptors in non-reproductive tissues is not known but may induce cell division and stimulate nitric oxide release. With constant activation following gonadectomy, these receptors are upregulated, further magnifying the effects of the extremely high LH concentrations in non-reproductive tissues. Canine gonadectomy increases the risk of several non-reproductive long-term disorders including hypothyroidism and hemangiosarcoma and this thesis research has demonstrated a causal relationship with LH receptor expression in these tissues.  
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  • 2017-08-22 to 2018-02-27

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