Nucleic Acid Based Therapeutics for Treatment of Cystic Fibrosis

Honors College Thesis

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Citeable URL: https://ir.library.oregonstate.edu/concern/honors_college_theses/z316q817j

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Attribute Name	Values
Creator	McKinney, Madison J.
Abstract	Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug available to treat all forms of this disease. This has made this disease attractive for gene therapy. Currently, studies are being performed using viral, and nonviral treatment methods. This paper reviews current gene therapy treatments for this disease, and details specific results regarding lipid nanoparticle delivery of CFTR mRNA for treatment of Cystic Fibrosis.
Contributor	Robinson, Ema MacDonald, Kelvin D. Slaughter, Kai Patel, Siddharth Sahay, Gaurav Sun, Conroy Jozic, Antony
License	Attribution-NonCommercial 4.0 (CC BY-NC 4.0)
Resource Type	Honors College Thesis
Date Issued	2020-06-02
Degree Level	Bachelor's
Degree Name	Honors Bachelor of Science (H.B.S.)
Degree Field	Bioengineering
Degree Grantor	Oregon State University
Commencement Year	2020
Advisor	Sahay, Gaurav
Committee Member	Patel, Siddharth Kelly, Christine
Non-Academic Affiliation	Oregon State University. Honors College
Urheberrechts-Erklärung	In Copyright
Publisher	Oregon State University
Peer Reviewed	No
Language	English [eng]

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