Honors College Thesis
 

Effects of Xanthohumol on Biomarkers of Metabolic Syndrome in Obese Rats

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  • 2014 Library Undergraduate Research Award winner
  • We tested the effects of a chronic feeding of XN on metabolic syndrome using a genetic model of obesity, the Zucker obese fa/fa (ZOF) rat. In 1962, the ZOF rat was found to .have an autosomal recessive mutation that prohibits the production of leptin. Leptin is a hormone involved in the regulation of energy intake and energy expenditure, which includes appetite and metabolism. The basic phenomenon in the fa/fa is an error in lipid metabolism. Due to a greater excess of lipids (probably low-density lipoproteins) circulating in the blood, an excessive amount of lipids is deposited in tissues; thus, overall ZOF rats become noticeably obese at 5 weeks of age [17]. Four-week old male and female ZOF rats were purchased from Harlan (Livermore, CA, USA). Animals were housed in individual cages in temperature and humidity controlled rooms with a 12: 12 on-off light cycle. All animals handling was approved by and in accordance with ethical standards of Oregon State University's Institutional Animal Use and Care Committee (Protocol # 3689). After a two-day acclimation period, male and female animals were divided into four treatment groups (n=6/group) according to their body weight to ensure similar average body weight across groups. For three weeks of the study, all rats were maintained on a high fat (60% kcal fat) AIN-93G to induce severe obesity, then placed on a normal AIN-93G (15% kcal fat) diet for the remainder of the study. Body weight and food intake was recorded weekly.
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