Index Catalog // ScholarsArchive@OSU

Method development for characterizing the hydrophobicity of engineered nanoparticles

Creator:: Lee, Fang Yu
Abstract:: Characterizing the hydrophobicity of nanoparticles can help us understand their fate and transport in the environment, as well as how nanoparticles may interact with biological systems. However, contact angle and partition coefficient have limitations in measuring the hydrophobicity of nanoparticles, thus promising methods to measuring the hydrophobicity of nanoparticles are...
Resource Type:: Masters Thesis
Full Text:: Stacey L. Harper Characterizing the hydrophobicity of nanoparticles can help us understand their

Investigation of film forming properties of beta-chitosan from jumbo squid pens (Dosidicus gigas) and improvement of water solubility of beta-chitosan, Investigation of film forming properties of β-chitosan from jumbo squid pens (Dosidicus gigas) and improvement of water solubility of β-chitosan

Creator:: Chen, Jeremy L.
Abstract:: The objectives of this project were to investigate the critical factors impacting the physicochemical and antibacterial properties of β-chitosan based films derived from jumbo squid (Dosidicus gigas) pens, and to evaluate the feasibility of improving water solubility of β-chitosan through Maillard reaction. The studies examined the effect of molecular weight...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Jeremy L

Bioactive and Biocompatible Coatings for Endotoxin Capture in Treatment of Sepsis

Creator:: Su, Jonathan
Abstract:: Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
Resource Type:: Honors College Thesis
Full Text:: LPS, and mutant azide-GP34 (modified with 4-azido-L-phenylalanine at N17, R58, and L81

Analysis and Modeling of Kinetic Parameters for Urea Hydrolysis by Bacteria for Use in Calcium Carbonate Precipitation in Aquifers

Creator:: Neighbor, Christopher J.
Abstract:: The use of ureolytic bacteria for the remediation of contaminated groundwater aquifers by inducing calcium carbonate precipitation is being studied in order to establish a better understanding of the modeling and prediction of how the bacteria will act in situ. This research has pursued the use of various ureolytic bacteria...
Resource Type:: Honors College Thesis
Full Text:: members Dr. Adam Higgins and Dr. Joe McGuire for their understanding and helpfulness. Thank you to the

Investigation of the effects of cryopreservation on cellular viability and mechanical integrity of the intervertebral disc

Creator:: Forcier, Ryan J.
Abstract:: Degeneration of the intervertebral disc (IVD) is a phenomenon that has yet to be adequately addressed. Treatment options remain limited and incomplete. The ability to effectively cryopreserve IVDs would allow for better allograft transplantations and storage of samples for research purposes. This study aimed to assess how cryopreservation with different...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

Fused Filament Fabrication of Filled Polymers for Metal Additive Manufacturing

Creator:: Barmore, Brenton
Abstract:: Additive manufacturing (AM) is a relatively new manufacturing technique that can create high complexity parts out of many materials in low volume. The fused filament fabrication (FFF) is the lowest cost AM process and is capable of producing only thermoplastic components. Powder injection molding (PIM) is a high volume low...
Resource Type:: Masters Thesis
Full Text:: sincere appreciation to… Professors Sundar V. Atre, David P. Cann, W.E. “Skip” Rochefort, and Adam Z

Development and Optimization of Medicinal Infused Hydrogel Patch and Cloth for the Treatment of Burn Patients

Creator:: Carpenter, Molly E.
Abstract:: Rapid and effective treatment of burn injuries is critical to prevent long term damage. Besides the pain associated with the burn injury due to damage and death of surrounding tissue and cells, there is a large risk for complications, particularly infection, following a burn injury. To address these risks, Meta...
Resource Type:: Honors College Thesis
Full Text:: _____________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

Hydroelastic modeling of a wave energy converter using the arbitrary Lagrangian-Eulerian finite element method in LS-DYNA

Creator:: Meicke, Stephen A.
Abstract:: This thesis investigates the applicability of the finite element method to model wave energy converter (WEC) hydroelasticity using LS-DYNA. The proposed methodology uses the Arbitrary Lagrangian-Eulerian formulation to model Fluid-Structure Interaction (FSI) between the WEC and the fluid elements. This formulation allows for time-domain modeling of higher order effects such...
Resource Type:: Masters Thesis

Spherical Au Nanoparticle Interaction with Lipid Monolayers Probed with Sum Frequency Generation Spectroscopy

Creator:: Faase, Ryan A.
Abstract:: Nanoparticles have become more prevalent from their use in sunscreen to antimicrobial agents in socks. In light of these applications, gaining a fundamental understanding of how NPs interact with humans is crucial for their future. Specifically, how cells interact with NPs and what factors drive the modes of cellular uptake....
Resource Type:: Masters Thesis
Full Text:: concentrations ≥ 20 mg/L in contrast to the 10 and 20nm AuNPs which showed no significant mortality in the

Predicting Treatment Options for the Intervertebral Disc: Patient-Specific Finite Element Models

Creator:: Ahrens, Sonia R.
Abstract:: This work describes a method for incorporating patient data into a nutrient transport model of the intervertebral disc.This data was collected using MRI diffusion weighted imaging (DWI), and was converted into an apparent diffusion coefficient map (ADC map). This map was used to define the diffusion behavior of water within...
Resource Type:: Honors College Thesis
Full Text:: ___________________________________________________________________________________________________ Adam Higgins, Committee Member, representing Bioengineering

Mass transfer of urea, creatinine and vitamin B-12 in a microchannel based membrane separation unit

Creator:: Warner-Tuhy, Alana
Abstract:: Micro energy and chemical systems (MECS) are microfluidic systems where energy and chemical processes can be intensified by decreasing the characteristic length. This project focused on bulk fluid processing using MECS technology to intensify the mass transport of a dialyzer. The objective of this project was to design a model...
Resource Type:: Masters Thesis
Full Text:: CONTENTS (Continued) Page L Hollow Fiber Dialyzer Data . . . . . . . . . . . . . . . . . . . . . . . 110

Signal Enhancement in Lateral Flow Tests for Infant HIV Diagnosis

Creator:: Rodriguez, Michael A.
Abstract:: Paper-based assays for HIV diagnosis are cheap, portable, and require little to no skilled training, electricity, or expensive equipment to perform successfully. However, there is a need for tests with lower limits of detection (LOD) for diagnosing infection at the earliest stages. Effective labeling to increase signal-to-noise ratio is critical...
Resource Type:: Masters Thesis
Full Text:: equation (Equation 2) is modeled as follows: 𝐿 = √ 𝛾𝑑𝑡 4𝜇 Equation 2. Lucas-Washburn equation

Investigating the Hemocompatibility of Blood-Contacting Biomaterials

Creator:: Hummel, Madeleine H.
Abstract:: Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
Resource Type:: Masters Thesis
Full Text:: committee members Dr. Kaitlin Fogg, Dr. Adam Higgins, and Dr. Bo Sun for their guidance, advice, and

Performance and flow stability characteristics in two-phase confined impinging jets

Creator:: Sabo, Michael D.
Abstract:: Advances in electronics fabrication, coupled with the demand for increased computing power, have driven the demand for innovative cooling solutions to dissipate waste heat generated by these devices. To meet future demands, research and development has focused on robust and stable two-phase heat transfer devices. A confined impinging jet is...
Resource Type:: Masters Thesis
Full Text:: , and Adam Damiano for the long hours of data collection they assisted with. TABLE OF CONTENTS Page

The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

Creator:: Alkhatib, Aveen K.
Abstract:: The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
Resource Type:: Masters Thesis
Full Text:: , 2.5 mM CaCl2, 22 g/L glycine, 3.1 g/L L-histidine and 10 g/L sucrose. The pH was then adjusted to

Design Automation for 3D Circuits

Creator:: Velayati, Mohammad
Abstract:: Traditional electronic systems are usually fabricated via printed circuit boards (PCBs). In a regular PCB, the electronic components are placed and mounted on a two-dimensional board. Such a component layout limits the freedom in the component placement process which results in larger electronic devices. With the use of Additive Manufacturing...
Resource Type:: Masters Thesis

Design automation for 3D circuits

Creator:: Velayati, Mohammad
Abstract:: Traditional electronic systems are usually fabricated via printed circuit boards (PCBs). In a regular PCB, the electronic components are placed and mounted on a two-dimensional board. Such a component layout limits the freedom in the component placement process which results in larger electronic devices. With the use of Additive Manufacturing...
Resource Type:: Masters Thesis

Processing effects on the ductility of chromium-vanadium alloys

Creator:: Murdock, Hailey M.
Abstract:: The next generation of high temperature structural alloys must exhibit exceptional resistance to fracture, creep, oxidation, and fatigue at high temperatures. Chromium is being considered due to its high melting point (>1800°C), relatively low density (~7.2 g/cc), high temperature strength, and oxidation resistance. Limiting the use of chromium is its...
Resource Type:: Masters Thesis

Synthesis and characterization of zero valent iron nanoparticles

Creator:: Coussens, Nathaniel J.
Abstract:: Synthetic methods for the preparation of magnetic nanocomposites with improved high frequency (into the GHz range) performance over conventional magnetic materials were examined. The most successful work involved synthesis of nanocrystalline zero valent iron particles (nc-Fe) through a reverse micelle method. Here, aqueous Fe(II) solution micelles formed using cetyl trimethylammonium...
Resource Type:: Masters Thesis

Synthesis and Characterization of an Ultrafine-Grained Aluminum-Copper System through High-Pressure Torsion

Creator:: Liang, Guangyuan
Abstract:: Aluminum and copper and their alloys have been widely used due to relatively high strength-to-weight ratios compared with conventional steels. Processing of these alloys is typically conducted at high temperatures over extended time periods. High-pressure torsion (HPT) is a promising processing technique for introducing significant grain refinement leading to excellent...
Resource Type:: Masters Thesis

Towards a Selectively Bioactive Surface for the Removal of Circulating Endotoxin in Blood

Creator:: Raman, Ramya
Abstract:: Sepsis is an inflammatory reaction occurring throughout the human body to infections caused by bacteria, fungi, and or other forms of pathogens. It is essential to find an alternative treatment method for sepsis, to lessen the dependence on antibiotics. Hemoperfusion is an absorbent device that removes select targets from blood,...
Resource Type:: Dissertation
Full Text:: am thankful for my wonderful committee: Dr. Joe Baio, Dr. Adam Higgins, Dr. Elain Fu, and Dr

Probing Structure, Selectivity, and Orientation of Biomolecules to Cell Membranes by Sum Frequency Generation

Creator:: Golbek, Thaddeus W.
Abstract:: Cell membranes act as barriers against unwanted movement of ions and biomolecules and are complex surfaces littered with protein channels, ion channels, cholesterol, and a myriad of different proteins. While this surface is extremely well studied, there is still much we do not know. The work in this dissertation demonstrates...
Resource Type:: Dissertation
Full Text:: .............................................................................................................… 116 6.3 Au NP uptake in embryonic zebrafish after 5 days exposure to 2.5 mg/L Au NPs...117 6.4

Grape and Wine Aroma Influenced by Vine Nutrient Status, Vigor and Crop Levels in Oregon Pinot Noir

Creator:: Yuan, Fang
Abstract:: Wine volatile composition is one of the most important constitutes of wine quality, and it is greatly influenced by number of factors. The studies herein were conducted to evaluate the grape and wine aroma affected by different vine nutrient status, vigor and crop levels of Oregon Pinot noir. In the...
Resource Type:: Dissertation
Full Text:: Cleary, and Dr. Adam Higgins for serving as my committee members and giving me assistance and guidance

Surface-Initiated Click-Ready Bioactive Polymer Coatings: Synthesis and Characterization

Creator:: Yu, Bonan
Abstract:: Protein adsorption on blood contacting medical devices usually causes fouling and failure, and may promote clotting and undesirable immune responses. Hydrophilic polymer coatings in a dense, pendent “brush” conformation can resist protein adsorption on the surface while increasing biocompatibility. Such coatings can also be used to immobilize a variety of...
Resource Type:: Dissertation
Full Text:: . Ryan Mehl, Dr. Adam Higgins, Dr. Brian Paul, and Dr. Vincent Remcho for their great help during my

Engineering an Ex-Vivo System to Study Transport Phenomena in the Human Intervertebral Disc

Creator:: Shalash, Ward
Abstract:: Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Resource Type:: Dissertation
Full Text:: Ph.D. study. I would like to extend my appreciation to my committee members, Dr. Adam Higgins, Dr

Development of Rapid Diagnostic Tools for Personal Health Monitors in the Context of Therapy Monitoring

Creator:: Wentland, Lael T.
Abstract:: Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Resource Type:: Dissertation
Full Text:: L of blood, with a time to result of four minutes. Detection was sensitive within the

Multi-Technique Characterizations of Natural and Biomimetic Adhesives

Creator:: Fowler, James E.
Abstract:: There have been many attempts to characterize and mimic natural fluid-based adhesive systems. However, very few of these studies have examined surface or interfacial interactions between adhesive and substrate. Furthermore, until now no study has used a combination of surface analytical and kinematic techniques to determine the precise chemical mechanisms...
Resource Type:: Dissertation
Full Text:: Mechatronics 19, 312-320. (doi:10.1109/tmech.2012.2234473). [2] Favi, P.M., Yi, S., Lenaghan, S.C., Xia, L

Development of Microfluidic Assays and Flow Control Tools on Porous Materials: Towards a Wound-Health Monitoring Device

Creator:: Downs, Corey J.
Abstract:: Remote health monitoring tools have significant potential to revolutionize the current healthcare paradigm. Such tools could improve efficiencies in healthcare by alerting patients and doctors to abnormal health conditions in real time, shortening the time to diagnose and treat ailments. To meet these needs, we pursue the development of fabric-based...
Resource Type:: Dissertation
Full Text:: mg/L and lesser infection categories, whose CRP measurements were ~30 mg/L. Thus, CRP measurements

Molecular origins of surfactant-mediated stabilization of protein

Creator:: Lee, Hyo Jin
Abstract:: Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
Resource Type:: Dissertation

Development of bi-based lead-free piezoelectric materials : thin film piezoelectric materials via PVD and CSD routes

Creator:: Jeon, Yu Hong
Abstract:: Piezoelectric materials have been widely used in electromechanical actuators, sensors, and ultrasonic transducers. Among these materials, lead zirconate titanate Pb(Zr[subscript 1‐x]Ti[subscript x])O₃ (PZT) has been primarily investigated due to its excellent piezoelectric properties. However, environmental concerns due to the toxicity of PbO have led to investigations into alternative materials systems....
Resource Type:: Dissertation
Full Text::  committee members Dr. David Cann, Dr. Mas  Subramanian, Dr. Janet Tate, and Dr. Adam Higgins for their

Film-forming ability of fish proteins

Creator:: Athaillah, Zatil Afrah
Abstract:: Characteristics of films obtained from fish myofibrillar proteins extracted from various solubilization methods were investigated. In this study, we utilized three agents to solubilize fish myofibrillar proteins from surimi, which are sodium chloride, sodium tripolyphosphate, and alkaline condition. The first part of this study focused on combination of sodium chloride...
Resource Type:: Masters Thesis

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