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Filtering by: Creator Frasier, Kaitlin E. Remove constraint Creator: Frasier, Kaitlin E. Degree Field Bioengineering Remove constraint Degree Field: Bioengineering

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  • Developing a Modular Analysis Pipeline to Identify Critical Matrisome Components in Gynecological Disease

    Creator:
    Cook, Carson J.
    Abstract:
    The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
    Resource Type:
    Masters Thesis
    Full Text:
    . Abstract approved: Kaitlin C. Fogg The matrisome is an ensemble of genes that are

  • Chandler Loop Model for the Development of Dynamic Hemocompatibility Assays

    Creator:
    Hasbrook, AnneMarie V.
    Abstract:
    A common issue with extracorporeal medical devices is blood clotting due to bio-incompatibility. Systemic anticoagulants are often prescribed to mitigate the coagulation issues. However, such drugs can lead to further complications, for example hemorrhaging. One solution to improve the hemocompatibility of blood-contacting medical devices are biomaterials, such as slippery liquid...
    Resource Type:
    Honors College Thesis
    Full Text:
    :_____________________________________________________ Joe E. Baio A common issue with extracorporeal medical devices is blood clotting due

  • Investigating the Hemocompatibility of Blood-Contacting Biomaterials

    Creator:
    Hummel, Madeleine H.
    Abstract:
    Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
    Resource Type:
    Masters Thesis
    Full Text:
    Abstract approved: ____________________________________________________ Joe E. Baio Surface

  • Phenotyping Degeneration of the Intervertebral Disc with Principal Component Analysis and K-Means Clustering

    Creator:
    Chen, Joseph
    Abstract:
    The human intervertebral disc (IVD) provides support for the vertebral bodies, allowing for movement and load bearing. The IVD can degenerate with age or injury, impeding function and causing chronic pain. Despite disc degeneration affecting over 90% of adults over age 50, and back pain being the leading global cause...
    Resource Type:
    Masters Thesis

  • SIMstat: Hardware Design Considerations for Implementing a Low-Cost, Portable Potentiostat

    Creator:
    Cook, Jacob M.
    Abstract:
    Electroanalytical techniques allow scientists and engineers to characterize bulk solutions as well as interfaces. Potentiostats are commonly used by researchers in a variety of disciplines to analyze the chemistry which occurs at a working electrode surface. Advancements in microelectronics and the proliferation of open-source designs have allowed researchers to construct...
    Resource Type:
    Honors College Thesis
    Full Text:
    : Potentiostat, Cyclic Voltammetry, Bioinstrumentation, Biosensors, Analog Design Corresponding e-mail address

  • Investigating the Role of Inflammation and Mechanical Loading in Orthopaedic Tissue Degeneration

    Creator:
    Benage, Lindsay G.
    Abstract:
    Orthopaedic soft tissue degenerative diseases significantly affect the population, especially as it ages. Degeneration is characterized by a progressive loss of extracellular matrix (ECM) components necessary for the proper functioning of the tissues and joints, eventually leading to pain and dysfunction. In humans, the intervertebral disc (IVD) and tendon are...
    Resource Type:
    Dissertation
    Full Text:
    analyzed the data. Isabelle E. Logan and Maria C. Franco provided technical and material assistance as