The potential for nanomedicine to reduce toxicity and improve therapeutic response to radiation is vast. Clinically, this potential has thus far only begun to be realized with the recent success of the radioenhancing nanoparticle, NBTXR3 by Nanobiotix. Radioenhancing nanoparticles, however, represent only a small class of nanomaterials that may be...
Current methods in traction force analysis rely on a homogeneous extra-cellular matrix and
embedded microbeads to track deformations. The efficacy of these methods decreases when the matrix is not homogeneous. In heterogeneous matrices, beads often aggregate in regions of higher matrix density and float in regions where matrix substrate is...
Cancer cell migration in three-dimensional extracellular matrix is a major cause of death for cancer patients. Although extensive studies have elucidated detailed mechanism of single cell 3D invasion and cell-ECM interaction, 3D collective cancer invasion is still poorly understood. 3D collective migration models have unveiled unexpected degrees of diversity and...
Cell migration is fundamental for physiological processes such as immune re-sponses, wound healing and development. It is also a critical characteristic of metastatic cancer cells. An extensive amount of studies have focused on 2D sub-strates in order to understand the mechanism of cancer metastasis. However, much less is known about...
The structure and mechanics of tissues affect many important cellular functions such as migration, differentiation, and growth. Mechanical interactions between cells and the extracellular matrix (ECM), as well as ECM-mediated mechanical communication between cells, plays a part in coordinating collective cellular dy- namics during critical processes such as morphogenesis, tissue...
Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
At the intersection of basic science research and clinical relevance, cancer metastasis and cell invasion is a multifaceted problem that has been investigated for the past several decades. Importantly, cancer cell plasticity, the ability of a single cell to change its phenotype without genetic mutations in response to environmental cues,...
This paper provides a literature review in order to capture the state of the Special Purpose Acquisition Company (SPAC) market, incorporating the most recent research from 2020 and 2021. SPACs are an alternative way to take a company public. Rather than going through the traditional IPO process to access public...
In this work, colloidal PbSe quantum dots (QDs) are shown to be synthesized in a controlled manner by changing the growth time and reaction temperature in a microwave synthesis method. It is explained why quantum dots make such a unique material to create electronic devices and the specific benefits that...
The mechanisms by which the activities of phospholipase C-β (PLC-β) enzymes are negatively regulated have not been well defined. We used cardiac-derived ratmyoblast H9c2 cells to investigate possible modes of regulation of PLC-β3 enzymes,the only endogenous β isoform abundantly found in these cells. The PLC-β3population in these cells was detected...
SAR11 Alphaproteobacteria are the most abundant aerobic chemoheterotrophs in ocean surface waters. Previous studies have indicated SAR11 cells play an important role in marine carbon cycling and consume up to half of some common dissolved organic compounds, such as amino acids. During sequencing of the first SAR11 genome, genes for...
This dissertation presents a phase domain in-loop-bandwidth spread-spectrum clock generation technique. In this proposed technique, a charge-based discrete-time loop filter is proposed to enable the phase domain in-loop-bandwidth spread-spectrum modulation without a delta-sigma modulator or time-to-digital converter. The in-loop-bandwidth modulation technique maximizes the loop bandwidth to improve phase noise suppression...
Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
The aim of this work was to assess the viability of duplex stainless steel 2205 components built via selective laser melting for seawater applications. First, a comprehensive additive manufacturing assessment was done. The duplex stainless steel 2205 components were selectively laser melted from gas atomized powder (D90 <45m) using a...
Heat-related fruit damage is a common problem in the northern highbush blueberry (Vaccinium corymbosum L). This is particularly true in regions such as the northwestern United States, where summers are warm and dry, and daytime temperature regularly exceeds 32 oC. Millions of dollars of fruit damage are reported in blueberries...
A low-voltage plateau at ∼0.3 V is discovered during the deep sodiation of Na₃V₂(PO₄)₃ by combined computational and experimental studies. This new low-voltage plateau doubles the sodiation capacity of Na₃V₂(PO₄)₃, thus turning it into a promising anode for Na-ion batteries.
Drosophila suzukii Matsumura (Diptera: Drosophilidae) are small invasive flies that in the past five years (2009-2014) invaded berry and stone fruit production regions in Europe and the Americas. Evolutionary adaptations, biological traits, and anthropogenic factors have contributed to its current status as a global pest. Females oviposit eggs into ripe...
The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
The integration of low-pressure membrane filtration and aerobic granular sludge (AGS) reactor leads to a novel environmental biotechnological process with strong potential to overcome membrane fouling and demonstrate excellent wastewater treatment performance. However, membrane fouling mechanisms in the AGS based membrane bioreactor (MBR) are lack of systematic elaboration. In the...
Pesticides benefit agriculture by increasing crop yield, quality, and security. However, pesticides may inadvertently harm bees, which are valuable as pollinators. Thus, candidate pesticides in development pipelines must be assessed for toxicity to bees.
Leveraging a data set of 382 molecules with toxicity labels from honey bee exposure experiments, we...
Machine Translation, the task of automatically translating between human languages has been studied for decades. This task is used to be solved by count-based statistical models, e.g. Phrase-based Statistical Machine Translation (PBSMT), which solves the translation problem by separately training a statistical language model and a translation model. Recently, Neural...
Approximately 12% of Americans do not consume the amount of zinc equal to the Estimated Average Requirement for zinc and could be at risk for marginal zinc deficiency. Zinc is an essential component of proteins in the defense against oxidative stress and DNA damage repair. Specifically in the prostate, zinc...
As the CMOS process scales down to submicron, digital circuit performance improves, while reduced supply voltage and lower transistor intrinsic gain make it difficult to implement analog circuits in a power efficient manner. Therefore, it has become advantageous to shift more analog signal processing functions conventionally realized in voltage (analog)...
Vibrio parahaemolyticus is a seafood-borne pathogen that can cause gastroenteritis in humans. This study investigated the effectiveness of refrigerated seawater (5°C) depuration on reducing V. parahaemolyticus in raw Pacific oysters (Crassostrea gigas). Raw Pacific oysters were inoculated with a mixed culture of five clinical strains of V. parahaemolyticus and depurated...
The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
An emerging strategy to reducing food waste is converting food processing byproducts to nutritious and inexpensive food ingredients. A relevant food processing waste stream is brewers’ spent grain (BSG), the primary byproduct of beer production. BSG is a promising candidate as a food ingredient because of its high protein and...
Local signal detection is useful in many scientific areas such as imaging processing and speech recognition, for extracting meaningful patterns from noisy signals. In this dissertation, we study estimation and local signal detection for spatial data distributed over irregular domains. In particular, we use bivariate splines defined on triangulations to...
Irradiation of a tryptamine linked through its side-chain nitrogen to an alkylidene malonate residue results in an intramolecular [2 + 2] cycloaddition to the indole 2,3-double bond. The resultant cyclobutane undergoes spontaneous retro-Mannich fission to produce a spiro[indoline-3,3-pyrrolenine] with relative configuration defined by the orientation of substituents in the transient...
Obesity and metabolic syndrome (MetS) affect over 1.9 billion adults and 12.7 million youth in the US. If all of today’s obese American youth become obese adults, the total societal costs over their lifetime may exceed $1.1 trillion. We show that feeding rodents a high-fat diet supplemented with xanthohumol (XN)...
In this work, we systematically explore the effectiveness of optical aberration correction over a wide range of optical depths using the Segmented and Zernike Polynomial bases. We manufacture a set of 16 optical phantom samples consisting of a clear polyester resin substrate embedded with varying concentrations of aluminum oxide (Al₂O₃)...
Water splitting is a green method being researched to produce green hydrogen in order to combat greenhouse gases emitted by the most popular energy source; fossil fuels. Water splitting involves two half reactions: hydrogen evolution reaction (HER) and oxygen evolution reaction (OER). Of these two, OER is the bottleneck water...
The Great Recession, which resulted from the burst of housing bubble and officially lasted from December 2007 to June 2009, started as a national recession in the U.S. and then affected countries across the world. Economies reacted differently to this recession and those systems that lost fewer jobs and/or recovered...
As the number of students and faculty involved in online learning in recent decades has increased, we recognize that there is a limited understanding of how learners react, interact, behave, and are served by the various components in the information delivery processes. When learning online without an instructor present in...
This paper is intended to perform cost-benefit, break-even and sensibility analysis of higher-place pond culture of Penaeus vannamei through a case study of a farmer in Zhanjiang City of Guangdong Province, using cost-benefit data about this farmer’s higher-place pond culture of Penaeus vannamei collected from field survey. Major findings of...
The desire to apply short-range wireless communication systems to telemetry sensor networks in a metal-enclosed chamber has prompted this study. This thesis will discuss the design of an infrared (IR) communication system for a wireless low-power, low-data- rate sensor network in a metal enclosure. This design requires an in-depth understanding...
The neutron flux-energy spectral characterization of a Thermo Fisher MP320 deuterium-tritium neutron generator was performed for two shielding configurations, one with substantial moderator between the source and the sample and one without such moderator. The STAYSL PNNL spectral adjustment code was utilized in conjunction with MCNP modelled reference spectra and...
Nonmelanoma skin cancer (NMSC) is the most common malignancy in Caucasian populations. One existing treatment modality for NMSCs is external radiotherapy delivered to the skin cancer tumor by a beta-emitter-containing radioactive skin patch. Alpha emitters, with their higher linear energy transfer than beta particles and shorter range in tissue, make...
Messenger RNA (mRNA) therapy has massive potential to treat various genetic disorders by providing effective proteins to the diseased cells and tissues. Its therapeutic applications include protein replacement, genome editing, and immunotherapy. For successful mRNA treatment, mRNA must be delivered to the cytosol of target cells. One of the leading...
The development and some applications of holographic optical tweezers (HOT) are presented. Our HOT system uses a spatial light modulator (SLM) to control the location and properties of the optical trap. We have developed a method for optimizing the diffraction efficiency of a SLM that can be applied in situ...
The phragmoplast associated kinesin, PAKRP2, from the model organism Arabidopsis thaliana is categorized as an orphan, or ungrouped, kinesin due to structural divergences from the established 14 kinesin families. An early study on PAKRP2 found that it localized to the phragmoplast mid zone during the late stages of cell division...
Cell division, arguably the most important event during the life cycle of the eukaryotic cell, is achieved through a complicated yet beautiful machinery. The mitotic spindle — a microtubule-based bipolar structure—is the cellular machinery responsible for the correct segregation of the genetic material, chromosomes. The protein-based nanomachines termed molecular motors...
This dissertation presents nonlinear terahertz (THz) properties of carbon nanomaterials investigated by time-resolved high-field THz spectroscopy. In order to determine THz characteristics of nanomaterials, we performed THz power spectrum measurement, THz raster imaging, THz time-domain spectroscopy (THz-TDS) and time-resolved pump-probe experiment on two different types of single layer graphene and...
In this comprehensive thesis, we present a series of experiments and findings that highlight the
critical importance of TDC Voltage Sensors in the hardware security domain. Our research begins
by introducing a novel self-calibrating module, demonstrating its efficiency through preliminary
calibration tests. We then delve into the Peak-to-Peak tests, which...
One of the biggest open questions in physics is the prevalence of matter over anti-matter in the present universe. One of possible answers lies in the violation of charge and parity symmetry in the lepton sector that would favor matter over anti-matter so that the universe becomes dominated by matter...
Nucleic acid therapeutics has cemented itself as one of the most efficacious and robust avenues for treatment of a wide range of diseases from vaccine development to treatment of liver, retina, cancer applications. Non-viral mediated gene delivery using lipid-based nanoparticle (LNP) carriers has proven its compatibility with addressing unexpected, fast...
Taking long-term electrical measurements of a large number of neurons simultaneously is required for many modern neuroscience experiments. However, such experiments are currently limited by the shortcomings of traditional neurosensing technology. For example, there is a significant mechanical mismatch between rigid silicon probes and soft biological tissues. This mismatch can...
Organic semiconductors have attracted considerable attention due to their applications in low-cost, solution-processable (opto)electronic devices. An important class of high-performance organic semiconductors is pentacene derivatives, which exhibit high charger carrier mobilities in field-effect transistors and ultrafast singlet fission in photovoltaic devices. These derivatives have served as benchmark materials for systematic...
In nanoscale materials, the Coulombic interaction between electrons are stronger than in bulk materials. These stronger interactions, caused by confinement and reduced dielectric screening, have interesting consequences for light-matter interactions. In carbon nanotubes (CNTs), strong interactions can enhance the impact ionization process, and thus assist photocurrent generation in CNTs. Conversely,...
Cancer is the second leading cause of death in the United States. To date, over 60% of current anticancer drugs were inspired by the discovery of chemical structure from nature, commonly known as a natural product. This work represents the biological characterization of several marine natural product compounds and their...
Organic semiconductors are used in a wide variety of applications including transistors,solar cells, and light emitting diodes. These materials are solution-processable,low cost, and tunable. Many successful organic optoelectronic materials utilizeblends of several types of molecules (such as donors and acceptors) in order topromote charge generation. As blends are an inherently...
Despite the prominence of LEDs in our society, we have limited knowledge pertaining to their long-term effects. These seemingly white LEDs have a large blue light component to them. Recent results have shown that Drosophila living in 12 hrs. of blue light and 12 hrs. of darkness live substantially shorter...
A construction project is considered to be unique due to the process of delivering a customer-designed product, diverse stakeholders involved, the unique location and timeframe of construction, and specific social, economic, and environmental constraints attached to it. The uniqueness of construction projects brought great challenges to the construction industry professionals...
The dissertation focuses on the engineering of light-matter interaction using plasmonic nanoparticles and metamaterials to achieve enhanced luminescence and based on which to improve the performance of biosensing and light-emitting technologies. We designed and fabricated a spectrum of nanostructures to exhibit particular dispersion relations capable of controlling the spontaneous emission...
Purpose: Model-based dose calculation algorithms (MBDCAs) have become clinically available within the past several years in commercially available brachytherapy planning systems. This work investigates the application of a 510(k) approved MBDCA Acuros™ BV and establishes a reproducible method of validation. The research is broken into three primary research goals. The...
The Comprehensive Nuclear-Test-Ban Treaty (CTBT) prohibits the testing of nuclear weapons on the face of the earth. The detection of atmospheric radioxenon (131mXe, 133m/133Xe, and 135Xe) plays an important role in the identification of sub-surface clandestine nuclear weapon explosions. Since the radioxenon identified above decay via two radiation in coincidence,...
Detection of xenon radioisotopes (radioxenons) has proven to be an important method for detecting nuclear explosions and is particularly well suited for detecting undeclared underground testing. The radioxenon isotopes ¹³¹mXe (t₁/₂ = 11.934 d), ¹³³mXe (t₁/₂ = 2.19 d), ¹³³Xe (t₁/₂ = 5.243 d) and ¹³⁵Xe (t₁/₂ = 9.14 h)...
The atmospheric detection of four radioxenon isotopes (131mXe, 133mXe, 133Xe, and 135Xe) released during a nuclear detonation is a key tool utilized by the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) to identify clandestine nuclear weapon testing activity. These radioxenon isotopes all decay via the near-simultaneous release of an electron and a...
Ideally, dosimetric models for pine trees will accurately reflect the doses to its critical organs. However, existing models (e.g. that in ICRP 108) for the pine tree are over simplified or solely focused on estimating doses to one specific organ, and none of the existing models attempt dosimetry to the...
Rainfall runoff erosivity (R) is one key climate factor that controls water erosion. Quantifying the effects of climate change–induced erosivity change is important for identifying critical regions prone to soil erosion under a changing environment. In this study we first evaluate the changes of R from 1970 to 2090 across...
Acetylene is a slow-binding inhibitor of the Ni- and Fe-containing dimeric hydrogenase isolated
from Azotobacter vinelandii. Acetylene was released from hydrogenase during the recovery from inhibition.
This indicates that no transformation of acetylene to another compound occurred as a result of the interaction
with hydrogenase. However, the release of C2H2...
Tooth decay in the form of dental caries and cavities is estimated to be among the most common health conditions globally, with treatment of these oral diseases resulting in a massive, world-wide economic burden. The cause of this demineralization of teeth is rooted in the action of complex microbial biofilms...
Web Information Discovery Tool (WIDIT) Laboratory at the Indiana University School of Library, whose basic approach to combine multiple methods as well as to leverage multiple sources of evidence, participated in 2005 Text Retrieval Conference’s Hard track (HARD-2005) to investigate methods of effectively dealing with HARD topics by exploring a...
The development of nuclear fuel and materials requires is a continuous effort to investigate the acute and prolonged effects of irradiation, thermal-material stress, chemical change, or other conceivable damage mechanics acquired during normal operation or accident scenarios throughout its lifetime. As in-core fuel property measurement techniques advance to support in...
Structure-specific synthesis processes are of key importance to the growth of polymorphic functional compounds such as TiO₂, where material properties strongly depend on structure as well as chemistry. The robust growth of the brookite polymorph of TiO₂, a promising photocatalyst, has been difficult in both powder and thin-film forms due...
The effect of particle shape on the strength, dilatancy, and stress-dilatancy relationship was systematically investigated through a series of drained triaxial compression tests on sands mixed with angular and rounded glass beads of different proportions (0%, 25%, 50%, 75%, and 100%). A distinct overall regularity parameter was used to define...
The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of...
Among early adolescents (10-14 years), poor diet quality along with physical inactivity can contribute to an increased risk of obesity and associated biomarkers for chronic disease. Approximately one-third of United States (USA) children in this age group are overweight or obese. Therefore, attention to factors affecting dietary intake as one...
Web Information Discovery Tool (WIDIT) Laboratory at the Indiana University School of Library and Information Science participated in the HARD, Robust, and SPAM tracks in TREC- 2005. The basic approach of WIDIT is to combine multiple methods as well as to leverage multiple sources of evidence. Our main strategies for...
This publication covers how pasture grows, understanding grazing systems, and forage quality. It also covers advanced tools for managing high-intensity grazing systems, such as the feed wedge (also called pasture wedge or grazing wedge).
The Northwest Forest Plan (NWFP), which aims to conserve late-successional and old-growth forests (older forests) and associated species, established new policies on federal lands in the Pacific Northwest USA. As part of monitoring for the NWFP, we tested nearest-neighbor imputation for mapping change in older forest, defined by threshold values...
Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Internal tide generation, propagation, and dissipation are investigated in Luzon Strait, a system of two quasi-parallel ridges situated between Taiwan and the Philippines. Two profiling moorings deployed for about 20 days and a set of nineteen 36-h lowered ADCP-CTD time series stations allowed separate measurement of diurnal and semidiurnal internal...
The thermal degradation of structural materials is considered to be a key factor for evaluating the lifetime of current nuclear power plants. Ni-based and Fe-based alloys, such as 690, 625, 304, and 316, are widely used in nuclear industry as structural components due to the extraordinary corrosion resistance and mechanical...
Hydrogen is the green fuel that can be produced from water through electrolysis and used via hydrogen fuel cells to generate electricity with zero carbon dioxide emission. The commercialization of electrolyzers and fuel cells is the critical step to achieving global carbon neutrality. However, it is severely hampered by the...
Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the...
Full Text:
Chen1,6,
Hanshi Xu3, Mingbang Wang3, Ting Ni7, Yang Li8, Han Yan8, Jin-Pei Zhang8, Chun Song8, Li-
Qing
Exposure to ultraviolet (UV) radiation is a primary cause of melanoma and non-melanoma skin cancer and thus represents a critical public health concern. Skin cancer risk behavior research lacks an instrument designed to assess health beliefs about UV exposure that may increase skin cancer risk by increasing risky UV exposure...
One fundamental concern in conservation biology is species abundance. For many taxa, however, these data are costly to obtain via direct observation and thus limited in geographic or temporal scope. Very high-resolution satellite imagery provides a means to address these limitations and provide remotely-sensed counts of large, colonial species. We...
We apply GENMOM, a coupled atmosphere–ocean climate model, to simulate eight equilibrium time
slices at 3000-year intervals for the past 21,000 years forced
by changes in Earth–Sun geometry, atmospheric greenhouse
gases (GHGs), continental ice sheets, and sea level. Simulated
global cooling during the Last Glacial Maximum
(LGM) is 3.8°C and...
Full Text:
., Vertenstein, M., Worley, P. H., Yang, Z.-L. and Zhang, M.: The Community
Climate System Model Version 4, J
Resolving the debate surrounding the nature and controls of seasonal variation in the structure and metabolism of Amazonian rainforests is critical to understanding their response to climate change. In situ studies have observed higher photosynthetic and evapotranspiration rates, increased litterfall and leaf flushing during the Sunlight-rich dry season. Satellite data...
Full Text:
greening
purely
an
artefact
of
variations
in
sun-‐sensor
geometry
Resolving the debate surrounding the nature and controls of seasonal variation in the structure and metabolism of Amazonian rainforests is critical to understanding their response to climate change. In situ studies have observed higher photosynthetic and evapotranspiration rates, increased litterfall and leaf flushing during the Sunlight-rich dry season. Satellite data...
Full Text:
, here we re-examine several years of
data from three sensors on two satellites under a range of sun
This study investigates the barriers faced by solar water heating (SWH) in the state of Oregon. SWH is a renewable energy technology (RET) that serves a functional purpose by heating water from a renewable resource (the sun) for practical commercial or domestic applications. Oregon currently experiences a low level of...
To effectively study dynamic processes like forest succession over long time periods one must effectively integrate data collected at many different times, locations and spatial scales. The purpose of this research is to integrate forest inventory data collected by the USDA Forest Service’s Forest Inventory and Analysis (FIA) Program with...
Radiation therapy is used in approximately half of all cancer treatments. The rapid advances in radiation therapy have led to techniques that are much more complex and therefore must be more carefully assessed for safety and efficacy. Accurate quality assurance methods must be implemented to provide patient safety and confidence...
Southeast Alaska is located on the traditional territory of the Lingít, Haida, and Tsimshian People. It is comprised of the largest temperate rainforest in the world, with subregions receiving over 500 cm of rain annually. Climate change is predicted to alter the region's timing, type, and magnitude of precipitation and...
Cutaneous melanoma remains the deadliest form of skin cancer, with a
diagnosis of metastasis indicating a median survival rate of less than a year. Solar ultraviolet (UV) radiation, especially childhood sun exposure, is an important etiological risk factor of melanoma. Previous studies determined that mice selectively lacking the nuclear hormone...
This study first investigated the developmental changes in the volatile composition and carotenoids of Pinot noir grapes. Grape berries were sampled every week from pea size to harvest during the 2011 and 2012 season. Carotenoids and organic acids were analyzed by HPLC. Volatile compounds were extracted from crushed berries using...
Understanding the interplay between energy and water is central to effective natural resource management. With enough energy it is possible to secure sufficient water, with enough water it is possible to produce nearly boundless energy. The sun is the engine which drives the availability of both these resources; nearly every...
Lifestyle factors are responsible for a considerable portion of cancer incidence worldwide, but credible estimates from the World Health Organization and the International Agency for Research on Cancer (IARC) suggest that the fraction of cancers attributable to toxic environmental exposures is between 7% and 19%. To explore the hypothesis that...
Daily cyclical changes of light are brought on by the axial rotation of the Earth while seasonal changes in light are caused by Earth’s tilt as it revolves around the sun. Major life history traits, such as development, which are tied to metabolic processes, have a strong link to the...
The influence of increasing temperatures on human health has been widely established across multiple health disciplines. Short-term temperature changes are associated with an increased risk of hospitalization and death overall and in a variety of health conditions, such as cardiovascular disease. Even as humans can self-regulate heat stresses, the elderly,...
Temuan World of Words offers tantalising glimpses into the
world of one of the indigenous Orang Asli communities of
Peninsular Malaysia.
The Temuan negotiate a way of life that sits uneasily in spaces
which have not yet been fully co-opted into the service of a
cash-based economy– spaces which still...
There has been a tremendous growth in interest in carbon nanodots (C-dots) in the past several years. As a nascent nanomaterial, C-dots have shown great promise in applications that benefit from their superior water dispersibility, low toxicity, non-blinking fluorescent output, chemical and biological compatibility, ease of functionalization and resistance to...
Transpiration (T), or the evaporation of water through plant stomata, plays a critical role in climate and biophysical processes at the earth’s surface. While T makes up a majority of the terrestrial evapotranspiration (ET) flux on a global scale, the partitioning of ET is variable and remains elusive. Because photosynthetic...
Polycyclic aromatic hydrocarbons (PAHs) are a class of contaminants ubiquitous in the environment and result from the incomplete combustion of fossil fuels. Many PAHs have been identified as procarcinogenic, and are metabolized to form DNA adducts; however, other mechanisms also may contribute to toxicity and help explain differences in toxicity...
Met is a prognostic indicator of colorectal cancer patient survival. Therapies that target Met may therefore have beneficial outcomes in the clinic. Recently, EGCG was reported to suppress Met activation, although the mechanisms were not elucidated. HCT116 and HT29 human colon cancer cells were used to examine the relationships between...
Surface-enhanced Raman scattering (SERS) has demonstrated single-molecule sensitivity and is becoming intensively investigated due to its significant potential in chemical and biomedical applications. SERS sensing is highly dependent on the substrate, where excitation of the localized surface plasmons (LSPs) enhances the Raman scattering signals of proximate analyte molecules. This paper...
The frequent misidentification of Asian garments in small museum collections indicated the need for a garment identification system specifically for use in differentiating the various forms of Asian clothing. The decision tree system proposed in this thesis is intended to provide an instrument to distinguish the clothing styles of Japan,...