Hydrogen sulfide emissions from the smelt dissolving tank area
of some kraft pulp mills exceed environmental limitations. There are
two main factors to consider in determining the cause of these emissions:
chemical equilibria and rate processes. This investigation
considers the chemical equilibria in the smelt shatter jet area (system
A)...
The fungitoxicity of acetone extracts from the xylem of Fusarium
wilt disease resistant tomato plants (cv. Jefferson) inoculated with Fusarium
oxysporum f. sp. lycopersici was greatly influenced by environmental
factors. Extracts obtained from plants 1 h after watering were 4-times
more toxic than extracts from plants subjected to water stress...
This investigation attempts to demonstrate that the development
of the early 20th century biological enterprise involved a striving for a
unifying theoretical perspective. A skeletal substantiation of this is
given by an overview of early 20th century biology in which some
biologists began recognizing a multiplicity of different orders of...
This study Is a rhetorical analysis of ten documents of Joseph
Smith, Jr's. early revelations spanning the period of 1829 to 1831
to determine the extent to which he used demagogic rhetoric in pursuit
of his goals. A definition of demagoguery is provided and is
applied in an analysis of...
Published July 1965. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
Infections in hospitals account for over 100,000 deaths per year. These infections occur at the
hospital from complications following bacterial adhesion to intravenous catheters, coronary
stents and other implanted devices. Another common problem is protein adsorption to the
surface of the device and subsequent blood clotting. Methods for combating these...
This dissertation presents novel, field-activated smart material systems for the actuation and control of autonomous robots. Smart materials, a type of material whose properties can be changed with an external stimuli, represent a promising direction to expand upon existing robotic control and actuation methods, particularly in the sub-fields of soft...
This thesis serves as a literature review of dashboards that calls for further research in the area of Feedback Mechanisms (FMs). A dashboard, for the purposes of this paper is a display used to provide performance feedback to a user. An FM is the mechanism used in a dashboard to...
The restoration of rivers and streams should be based on a
strong conceptual framework. Streams are developing systems. As
such, streams exhibit temporal behaviors that change with changing
stream environments. Underlying the dynamic development of streams is
potential capacity. Streams express this capacity as an array of
habitats over time...
The vertical and radial components of a seismic P wave can be
decomposed by a Fourier transform into two sets of nonterminating
sinusoidal waves with one set for each component. The tangent of the
vertical transform divided by the radial transform gives by definition
he apparent angle of emergence for...
The first cycle of seismic waves recorded at distances of 45,
300 and 355 km. from the GNOME nuclear explosion was used to determine
whether the near source wave characteristics at 0.3 km.
could be determined from distance measurements. Both head wave
and body wave propagation were considered. First the...
Confederate governors Joseph Brown and Zebulon Vance have long been considered obstructionists to the Confederate cause through their steadfast commitment to states' rights. States' Rights Nationalists throws in its own interpretation of these two men into the historiographical conversation taken on by well-known Civil War historians like Frank Owsley, Albert...
Contact of blood with the surfaces of synthetic materials is associated with spontaneous protein adsorption, initiating platelet aggregation, the coagulation cascade, and the eventual development of a stable clot. Current therapy to inhibit implant-induced thrombosis is life-long administration of systemic anticoagulants. An alternative to the systemic administration of anticoagulant drugs...
Four species of euryhaline teleosts (chinook salmon, Oncorhynchus
tshawytscha, Walbaum; staghorn sculpin, Leptocottus armatus,
Girard; starry flounder, Platichthys stellatus, Pallas; shiner perch
Cymatogaster aggregata, Gibbons) were exposed to x-rays. The irradiated
animals were maintained in either of two different environments.
The effects of x-radiation were determined by observing the
percent...
The partitioning of body fluids in the Pacific hagfish was investigated
using several experimental techniques. Direct measurement
of the blood volume was obtained through the simultaneous use
of tagged red blood cells and plasma proteins labeled with Evan's
blue dye. Blood cells obtained from donor animals were incubated
with L-methionin-methyl-C¹⁴...
Apoplastic distribution patterns of atrazine [2-chloro-4-(ethylamino)-
6-(isopropylamino)-s-triazine], glyphosate [N-(phosphonomethyl)-
glycine], the naturally occurring apoplastic leaf solutes, and
the apoplastic dye PTS (trisodium 3-hydroxy-5,8,10-pyrenetrisulfonate)
were compared. Aliquots of sap were expressed from intact
sunflower leaves in a pressure chamber over intervals of 0.2 to 0.4
bars. Three distinct fractions were detected...
In study 111, four Douglas-fir (Pseudotsuga menziesii (Mirb.) Franco) stocktypes (1-0, 2-0 standard nursery run and low density bareroot seedlings, and 1 year old container stock) were outplanted in a randomized
incomplete block design to an old field in the Willamette Valley of Oregon in a factorial experiment t4 stocktypes...
The purpose of this study was to investigate the use of a multistage with probability proportional to size (FPS) sampling design using
aerial photography to sample coniferous regeneration on clearcuts.
To date, aerial photography has not proven to be as economical
(because of the high cost of specialized photography required)...
The purpose of this study was to investigate: (1) whether the use of the Motions computer program will be more effective in the acquisition of transformation geometry concepts in eighth-grade students than the use of the Mira hands-on manipulative, (2) whether the use of the Motions computer program will be...
Wetland soils with complex stratigraphy and redoximorphic features occur on the
margin of the Willamette Valley, Oregon. In the Jackson-Frazier wetland, vertisols
show three distinct stratigraphic units that rest uncomformably upon each other and
correspond to the Bashaw series Bss, 2Bt and 3BC horizons. Holocene alluvium
deposited as distal alluvial...
The seasonal concentration, turnover and mode of accumulation
of ³²P by the juvenile starry flounder in Alder Slough, a small eco-system in the Columbia River Estuary, was examined during 1969 and
1970.
Levels of ³²P and concentrations of total P were measured to
permit computation of specific activities (nCi³²P/g total...
Passage of blood through a sorbent device for removal of bacteria and endotoxin by specific binding with immobilized, membrane-active, bactericidal peptides holds promise for treating severe blood infections. Peptide insertion in the target membrane and stable binding is desirable, while membrane disruption and release of degradation products to the circulating...
The use of bromoxynil (3,5-dibromo-4-hydroxybenzonitrile)
to control broadleaf weeds in cereal crops has become widespread.
This herbicide has not always performed satisfactorily for reasons
which were not clearly evident.
The effects of temperature, light and humidity on the herbicidal
activity of bromoxynil on coast fiddleneck, Amsinckia intermedia,
were studied. Fiddleneck...
Biological interrelationships between the ambrosia beetle
Xyleborus dispar (F.) (Coleoptera:Scolytidae) with its symbiotic
fungus, Ambrosiella hartigii Batra (Fungi Imperfecti) were investigated
in western Oregon.
Postdiapause adults of X. dispar collected in March through
June with rotary nets, and excised from overwintered and newly
attacked host material, produced a single generation...
I radio-tagged 191 Hatch-Year (HY) and After-Hatch-Year (AHY) female northern pintails (Anas acuta) in the San Joaquin Valley (SJV), California and studied their movements, habitat use and survival during August March, 1991-94.
Overall, 94.3% wintered in central California; the highest percentage left during
the 1991 drought. Tulare Basin and Mendota...
Managing riparian areas in the dry forests of the intermountain west for diverse public values can create conflict, potentially limiting social acceptance in landscape-scale restoration projects. This thesis examined accelerated landscape-scale restoration as part of a broader shift toward ecosystem management on national forestland, which incorporates social values into forest...
Passive hydrophone technologies and a variety of acoustic methods are applied in
the deep-ocean and shallow water coastal environments of the northeast Pacific. A
catalog derived from U.S. Navy regional hydrophone array recordings of acoustic T- phases from seafloor earthquakes is examined, describing space/time patterns through
empirical orthogonal function analysis...
It was the goal of this research to determine if sago
starch could be used to replace wheat flour as an adhesive
extender of Urea-formaldehyde plywood adhesives through
either chemical modification of the starch or modification
of the adhesive formulation strategy. Guiding principles of
the research would be that a...
Microplastics are ubiquitous in our oceans, yet we are still clarifying what risks they pose to marine organisms, which can be challenging due to their trait diversity and spatial patchiness. Laboratory-based studies assessing risk demonstrate that many marine animals internalize microplastics, either actively through ingestion or passively via respiration. However,...
Altogether, this dissertation highlights the value of mass spectrometry-based analysis of intact proteins for solving problems related to understanding disease mechanisms and developing new therapeutics.
Mutations to the antioxidant enzyme Cu, Zn Superoxide Dismutase (SOD1) perturb protein structure in vivo to cause 2-5% of amyotrophic lateral sclerosis (ALS) cases. Metal-deficient...
The purpose of this research was to determine if there were any relationships between measured personality traits and vocational interests between the Adult Learner with Learning Disabilities (ALLD) and without Learning Disabilities (ALNLD). Instruments utilized to measure personality traits and vocational interests included the Myers Briggs Type Indicator (MBTI) and...
Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive degeneration of motor neurons. Dominantly-inherited mutations to the antioxidant enzyme Cu,Zn superoxide dismutase (SOD1) cause 3-6% of all ALS cases. The complete mechanism behind the toxicity of mutant SOD1 remains unclear, although significant evidence points to aberrant or...
The study was designed to assess the efficacy of Lou and Charlson's
(1991) social cognition training program for deaf adults. Sixteen deaf
adult subjects who were vocational rehabilitation clients, and who had
been identified as experiencing difficulties in social functioning, were
assigned to receive a eight-week training program designed to...
Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
:
___________________________________________________________________________
Joseph McGuire
Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate
The ever-increasing global population presents looming problems for the field of agriculture. Global food demand will, at some point, increase to the point where there is not enough crop-ready land to keep up. This creates an additional incentive, other than economics, for growers to increase their yield-per-acre and make sure...
Rhizopogon salebrosus is an abundant ectomycorrhizal fungus common throughout Western North America that forms mutualistic partnerships with Pinus species. Studied for its systematics, use in sapling nurseries, post-fire seedling establishment, and unique evolutionary history, R. salebrosus holds many secrets within its genome. This thesis aims to characterize the mating system,...
:
_____________________________________________________________________
Joseph Spatafora, Mentor, representing Department of Botany and Plant Pathology
Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram-positive bacteria, was incorporated into novel block copolymer constructs and tested for retained antibacterial activity. Covalent coupling was achieved by chemical modification of the N-terminal isoleucine to introduce a thiol group. Thiolated nisin derivatives were then linked to poly[ethylene...
:
_____________________________________________________________________
Joseph McGuire
Nisin, an antibacterial peptide proven to be an effective inhibitor of Gram
Adsorption kinetic data recorded for α-lactalbumin, β-casein, β-lactoglobulin, bovine serum albumin and lysozyme at silianized silica surfaces of low and high hydrophobicity, along with a simple model for adsorption and surfactant-mediated elution of protein, were used to analyze the removal of each protein by sodium dodecylsulfate (SDS) and dodecyltrimethylammonium bromide...
The goal of this thesis is to ease the adoption of energy-efficient (EE) building strategies for affordable homes in the United States (US). Low-wage earning households spend nearly three times the proportion of their gross annual income on home energy bills resulting in higher energy burden for them when compared...
Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Nisin is an antibacterial peptide, which when adsorbed
on a surface can inhibit bacterial adhesion and viability.
The ability of noncovalently immobilized nisin to withstand
exchange by the milk proteins bovine serum albumin, β-lactoglobulin, α-lactalbumin, and β-casein on surfaces that
had been silanized with dichlorodiethylsilane to exhibit
high and low...
In the past two decades, the advancement in data collection and storage have led to the accumulation of complex datasets. Consequently, various industries have sought data-driven solutions to predict and detect anomalies. Temporal patterns have emerged as potential features in prediction models that could improve the performance of the identification...
Interactions between proteins and contact surfaces can have
important implications in the food industry. Such interactions
contribute to the course of fouling of membrane surfaces and they
appear to mediate bacterial and spore adhesion to some degree as
well. In addition to protein and solution properties, interfacial
behavior is strongly...
The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for
biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
:
______________________________________________________________
Joseph McGuire
The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling
A more quantitative understanding of peptide loading and release from polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. The antimicrobial peptide nisin shows potent activity against Gram-positive bacteria including the most prevalent implant-associated pathogens, its mechanism of action minimizes the...
Oxygen derived radicals are involved in many aspects of life from aging and cell signaling to disease states as diverse as heart disease, diabetes, neurodegeneration and inflammation. Therefore, understanding the function of antioxidant defense proteins and the effects of oxygen derived radicals on protein function is essential to elucidate the...
The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
:
_____________________________________________________________________
Joseph McGuire
The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the
This thesis is a comparative study of the two processes of currency change that occurred in Ecuador in 2000 and in France in 2002. Although the background of these two countries and the motivations behind each currency change varied, Ecuador and France have experienced many similar outcomes. Each of the...
The strained carbon ring, bicyclo[1.1.1]pentane, was synthesized by a reaction between
1-(phenylsulfanyl)bicyclo[1.1.1]pentane, prepared from propellane, and Raney nickel.
Infrared spectra were recorded at a resolution of 0.0015 cm-1, a resolution significantly
better than previous measurements, 0.06 cm-1. A single fundamental band was analyzed
to determine the ground state and excited...
Highway work zones are extremely dangerous environments due to the presence of workers near high-speed traveling vehicles. This dynamic environment results in a disproportionate number of accidents that cause injury and casualty to both drivers and workers due primarily to vehicular intrusions into work zones. Several emerging work zone intrusion...
The adsorption and elution of the antimicrobial peptide nisin at hydrophobic,
silanized silica surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-
poly[ethylene oxide] surfactant Pluronic® F108 was measured in situ, with ellipsometry.
While such layers are known to inhibit protein adsorption, nisin was observed to adsorb in
multilayer quantities, to an...
:
________________________________________________________________________
Joseph McGuire
The adsorption and elution of the antimicrobial peptide nisin at
Perdeutero-spiropentane (C₅D₈) has been synthesized and infrared and Raman spectra are reported for the first time. Wavenumber assignments are made for most of the fundamental vibrational modes. Gas phase infrared spectra were recorded at a resolution (0.002 cm⁻¹) sufficient to resolve individual rovibrational lines and show evidence of strong Coriolis...
Heparin was modified and immobilized to surface-activated silica surfaces using two different reaction schemes. End-aminated heparin was reacted with 2-iminothiolane to produce free thiol groups at the terminal ends of the heparin chains. The end-thiolated heparin was immobilized by reaction with a pyridyl disulfide activated poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] triblock...
:
_____________________________________________________________________
Joseph McGuire
Heparin was modified and immobilized to surface-activated silica surfaces
The role of the nonionic surfactant Tween 80 on the behavior of the therapeutic recombinant protein Factor VIII (rFVIII) was investigated at solid/liquid and air/water interfaces. In order to provide a model system to compare results obtained for the complicated rFVIII-Tween system, a well-characterized globular protein lysozyme was used. The...
The adsorption kinetics exhibited by selected charge mutants of T4 lysozyme at
silanized silica surfaces were monitored with in situ ellipsometry. Mutant lysozymes were
produced by substitution of lysine (Lys) with glutamic acid (Glu). Each substitution
resulted in a decrease in the net charge of the protein by 2 units....
The capability of Pluronic® F68 to stabilize human recombinant Factor VIII in solution was
assessed using zeta potential measurements. Hemophilia A is a genetic disorder in which the
body is missing Factor VIII (FVIII) from the blood coagulation cascade. The pharmaceutical
industry developed recombinant Factor VIII (rFVIII), the largest cloned...
Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
HIV testing among high risk adolescents in Dar es Salaam, Tanzania is challenging due to poor access to test sites and AIDS-related social stigma. We adapted the OraQuick HIV Test, a self-implemented test (SIT), for low literacy youth with no internet access. To compensate for poor literacy, a picture instruction...
The continuous improvement of construction operations requires a systematic approach of monitoring and making appropriate control actions. However, the lack of real-time information hinders this workflow and eventually compromises timely and effective decision-making. Project managers spend a great deal of time and effort to solve problems emerging from lack of...
Heparin was modified with adipic diliydrazide and covalently linked to surface-activated silica. Contact angle measurements were made to determine changes in surface at various stages of the derivatization. Xray photoelectron spectroscopy was used to analyze the elemental composition of the surface at each step of immobilizing heparin as well and...
The two primary considerations for highway work-zones are its effect on commuter mobility and worker safety which are often spoken of together. However, it must be noted that they often conflict with each other. For example, traffic control plans that reduce travel speed in work-zones improve both commuter and worker...
Adipic dihydrazide-modified heparin was prepared and
subsequently immobilized on surface-activated silica wafers. X-ray
photoelectron spectroscopy (XPS) was used to quantify the elemental
composition of the silica surface at each stage of activation and results
showed that successful immobilization had taken place. Contact angle
measurements were made to verify the high...
Debris generated after a disaster event must be disposed efficiently for community recovery. This is a significant operation that accounts for up to 27% of the total recovery costs. Generally, debris removal takes place in two phases: the short-term relief phase, which involves debris removal immediately after a disaster to...
Environmental magnetic techniques have been used to discriminate sources of sediments from a variety of natural and anthropogenic sources. In many studies, magnetic properties such as susceptibility, have served as a proxy for heavy metal concentrations. In these cases, there tends to be enhancement of magnetic minerals. The study presented...
The surface tension kin'ti4tnd ste'dy state behavior exhibited by mixtures of selected
surfactants with a recombinant Factor VIII (rFVIII) were evaluated with automated
interfacial tensiometry. In particular, fresh solutions of rFVIII with different concentrations
of Tween 80, sodium dodecylsulfate (SDS), or dodecyltrimethylammonium bromide
(DTAB) were prepared and their surface tension...
Surface tension kinetics exhibited by selected stability mutants of T4 lysozyme at the air-water interface were monitored with DuNoüy tensiometry. Mutant lysozymes were produced by substitution of isoleucine at position 3 with cysteine, leucine, tryptophan and glycine. Each substitution resulted in an altered structural stability quantified by a change in...
Amyotrophic Lateral Sclerosis (ALS) is a relatively rare neurodegenerative disorder that is fatal 2-4 years after the onset of the disease. Population studies are being done in order to help reveal candidates for further studies of disease etiology, disease progression, as well as to further understand racial and ethnic variations....
The primary goal was to characterize the adsorption of a recombinant therapeutic protein
in the presence of selected surfactant species at the air-water interface. For this purpose,
dynamic interfacial tensiometry was used to determine the surface tension kinetics
exhibited by protein solutions containing either Tween 80 or the poly[ethylene oxide]-...
Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...