Proportion data falling in the continuum (0, 1) are very common in practice. It can also happen that an inflated number of zeros (or ones) occur with proportion data. There are extensive studies of zero-inflated data in the literature. Almost all of them, however, focus on zero-inflated count data. Furthermore,...
This thesis proposes an approximate maximum likelihood estimator and
likelihood ratio test for parameters in a generalized linear model when two or
more random effects are present. Substantial progress in parameter estimation
for such models has been made with methods involving generalized least squares
based on the approximate marginal mean...
Two novel and highly related C₂H₂ zinc finger proteins (CTIP1/BCL11A/EVI9 and CTIP2/BCL11B/Rit1) have been implicated in COUP-TF signaling, etiology of myeloid and lymphoid malignancies, and hematopoietic cell development. However, the precise cellular function(s) and the contribution of these proteins to neoplastic processes and hematopoietic cell development remain unknown. The goal...
Throughout most of the developed world, surgical sterilization via gonadectomy has become a common tool for combating the overpopulation of unwanted dogs as well as to eliminate the risk of reproductive diseases in pet dogs. In the dog as in other normal adult mammal, the hypothalamus secretes gonadotropin-releasing hormone (GnRH),...
BCL11B is a transcriptional regulatory protein that plays essential roles during mouse embryonic development. BCL11B is expressed and functions in the immune and nervous systems as well as within ectodermal organs. Multiple studies have characterized the roles of BCL11B in T cells, brain, and skin. However, very little is known...
Differential expression (DE) analysis allows us to identify genes that respond differently under varying experimental conditions, therefore granting us an understanding of the molecular basis of phenotypic variation. Following the identification of significantly differentially expressed genes, it is often of the researcher's interest to elucidate hidden patterns or groups in...
Calcium channel blockers (CCB) was studied extensively in cardiology for their tissue
protective effect following myocardial infarction; we hypothesized that administration of
a CCB would interfere with the processes that result in exercise-induced muscle damage
(EIMD) and delayed onset muscle soreness. To investigate the effects of a CCB on a...
Modern geospatial data are frequently represented in some type of three-dimensional (3D) coordinate system, for example geodetic latitude, longitude, and ellipsoid height (φ, λ, h) derived from Global Navigation Satellite Systems (GNSS). But for engineering and surveying work, φ, λ, h coordinates are usually converted to a topocentric system consisting...