Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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. Bhat, Jeff M. Blaney, Evan Bolton, Gerard Bricogne, David
Brown, StephenK. Burley, David A. Case, Kirk
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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Bolton,9 Gerard Bricogne,10 David Brown,11,12 StephenK. Burley,5,6,13,* David A. Case,6
Kirk L. Clark
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
The preservation of land, such as wetlands and agricultural
lands, is often pursued through traditional methods such as zoning or
eminent domain. Transferable Development Rights provides a different
approach to the preservation of land by allowing the sale and transfer
of development rights from land to be protected to land...
The influence of overstory openness on the reproductive
ecology of Pacific yew (Taxus brevifolia Nutt.) was
investigated on 4 sites in western Oregon over 2 years. The
breeding system of T. brevifolia was found to deviate from
pure dioecy under a broad range of canopy and site
conditions. Production of...
Anchors resistant to tensile loads are commonly used in civil engineering practice. Anchors in the marine environment are most frequently used for the mooring of vessels. Only recently, with the expansion of the offshore industry, has the need to develop more reliable anchor systems become necessary. Embedded plate anchors are...
The use of electronic cigarettes (often referred to as vapes or e-cigs) has grown rapidly in the past decade. While these devices may not deliver the same level of carcinogens and toxicants as combustible cigarettes, they can deliver nicotine (a known developmental toxicant) as efficiently. Previous work suggests that, during...
The Soil Conditioning Index (SCI) aids the conservationist in designing crop rotations and residue management practices when low organic matter, poor soil tilt, and crusting problems are identified. The Natural Resources and Conservation Services (NRCS) field staff and others use the SCI as a qualitative tool during conservation planning. In...
The heritability of resistance to eastern filbert blight, caused by Anisogramma anomala, in European hazelnut (Corylus avellana) was evaluated in the progeny of seven cultivars crossed in 12 combinations. Progeny produced by crossing 'VR6-28' with three susceptible cultivars segregated 1:1 for complete resistance to eastern filbert blight. Histograms of disease...
Interactions between proteins and contact surfaces can have
important implications in the food industry. Such interactions
contribute to the course of fouling of membrane surfaces and they
appear to mediate bacterial and spore adhesion to some degree as
well. In addition to protein and solution properties, interfacial
behavior is strongly...
'Alba' (Reg. No. [CV-355, PI 672535]) is a winter, six-row barley released by the Oregon Agricultural Experiment Station in 2012. The name “Alba” was chosen due to the bright and attractive appearance of the crop at maturity. In high rainfall environments, it has a notable yield advantage over check varieties...
Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a
soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and
3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂
upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production.
Two common FMO2 (the major...
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Hydrogen Peroxide
Siddens, L. K., Krueger, S. K., Henderson, M. C., & Williams, D. E. (2014).
Mammalian
Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
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Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
Full Text:
Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Responses to two cycles of mass selection for heading date,
followed by selfing or intermating, were studied in two diverse
winter wheat (Triticum aestivum L. em. Thell) crosses. Selection
was bidirectional, resulting in early and late populations for
each mating system, cycle, and cross. The influence of mass
selection for...
The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Published September 1978. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The cockpit is an environment in which many important tasks simultaneously
compete for pilot attention. Cockpit Task Management (CTM) is the process by
which pilots selectively attend to flight tasks in such a way as to safely and
effectively complete a flight. CTM has been categorized as a mental function...
Although the potato (Solanum tuberosum L.) is a global crop, few growing regions rival the high yields of the Columbia Basin of Eastern Oregon and Washington. Two research projects were conducted in Hermiston, OR to contribute to best management practices for the region. The first project evaluated the efficacy of...
Published February 1992. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Near-surface advanced argillic hydrothermal alteration zones, also referred to as lithocaps, are characterized by quartz, alunite, clays (pyrophyllite and kaolinite group minerals), and minor F-bearing aluminosilicates (i.e., topaz, zunyite, diaspore, and APS) that form where water-, SO2-, and HF-rich gas condenses into shallow groundwater, acidifies, and reacts with rocks. The...
The purpose of this study was to examine the experiences of foster alumni in community and technical colleges, with a focus on Washington State, using a qualitative research approach. Foster alumni may be considered a sub-set of first generation students, yet they have needs that extend beyond those of other...
This thesis involves analyses of 3₂-helices, a-helices and of the change in residual
entropy of a protein upon chemical modification. Part of the long-term goal of
understanding the formation, function and stability of proteins requires that all
conformations be accurately assigned and structurally understood. By a statistical
analysis of 258...
We evaluated effects of chemical fertilizer, spacing, and interplanted nitrogen-fixing trees on wood density and diameter growth of 15-year-old Eucalyptus saligna trees. The trees were grown in silvicultural trials established on former sugarcane land on the island of Hawaii. Elevation was 480 m, slopes were gentle, and annual rainfall averaged...
We have developed crown-gall resistant transgenic plants capable of suppressing Agrobacterium tumefaciens T-DNA oncogenes. Crown gall tumors result from overproduction of auxin and cytokinin in plant cells transformed by A. tumefaciens. High phytohormone levels result from expression of two auxin biosynthetic genes, tryptophan monooxygenase (iaaM) and indole acetamide hydrolase (iaaH),...
Plum pox virus (PPV) is a member of the Potyvirus genus that, in nature, infects trees of the Prunus genus.
Although PPV infects systemically several species of the Nicotiana genus, such as N. clevelandii and N.
benthamiana, and replicates in the inoculated leaves of N. tabacum, it is unable to...
The epiphytic lichen Letharia vulpina has been commonly sampled in-situ for nitrogen (N) deposition biomonitoring studies but has never before been transplanted for this purpose. In the high-elevation wilderness areas of southern California Letharia vulpina is generally uncommon, making in-situ sampling difficult. In this study, we compared thallus N accumulation...
Instream flow protection in western prior appropriation states is a relatively new phenomenon.
Integrating instream flow protection measures with the older water law has been accomplished with varying
degrees of success. Idaho relies on appropriation of unappropriated water by the Idaho Water Resource Board
for protection of instream flows. Idaho's...
Academic success is a salient domain of youth development and is related to positive lifelong outcomes among youth in foster care. However, youth in foster care experience compounding adversities, including maltreatment and foster care placement itself, which put them at risk of academic disengagement and underachievement. Despite these adversities, academic...
This manuscript describes the role of non-classical hydrogen bonds (NCHBs), specifically C–H···O interactions, in modern synthetic organic transformations. Our goal is to point out the seminal examples where C–H···O interactions have been invoked as a key stereocontrolling element and to provide predictive value in recognizing future and/or potential C–H···O interactions...
The "Framework for Determining the Suitability of Undeveloped
Land for Use as Cropland" is a decision-making format to assist private
and governmental agency decision makers in categorizing undeveloped
lands, which have been identified as having potential for conversion
to cropland, as to their suitability for use as cropland. The
Framework...
Published June 1998. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The objective of this study was to compare the effects on eating behavior,
lipids, lipoproteins, lipid peroxidation, and glycemic control in women with type 2
diabetes of a high-monounsaturated fat diet (HM) compared to a high-carbohydrate
diet (HC).
In an outpatient feeding study, ten hypertriglyceridemic postmenopausal type
2 diabetic women...
This thesis consists of three manuscripts addressing separate components of barley breeding, plus an introduction and a conclusion summarizing the status of barley in the Pacific Northwest, plus the implications of the research presented in this thesis. In the first manuscript, a package written for the statistical software "R" that...
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, Dr.
Don Obert, Dr. Kevin P. Smith, and Dr. Stephen Ullrich contributed germplasm that was
Published April 1993. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Butter has long been the premium choice for producing pastries such as Danish and croissants. Its inclusion has consistently delivered characteristically light and airy crumbs with beautifully flaky crust. Once considered a delicacy, pastries have now become innocuous in our everyday lives. Once requiring a skillful hand to sculpt and...
Cyclopropenoid fatty acids (CPFA) are natural components of
cottonseed oil, a major food oil in the United States. The ability of
CPFA to cause abnormal biochemical and physiological effects when
fed to laboratory and farm animals has prompted an investigation of
their effects on mice.
Between 0.05 and 0.55% CPFA...
Peppermint, Mentha piperita 'Black Mitcham' was established as a host for tomato
spotted wilt virus-impatiens serotype (TSWV-I). TSWV-I infection of peppermint,
initially observed in a research greenhouse (Corvallis, OR), included stunting and
downward curling of leaves accompanied by bronzing, and occasionally tip necrosis.
Young leaves appeared either symptomless, deformed, or...
Persistence has been identified as an issue at all levels of higher education,
and numerous strategies have been attempted to stem the flow of students who leave
an institution before completing their programs of study. Persistence research
abounds at the community college, four-year college and university levels, but little
research...
This dissertation presents a study of structure-property relationships within 3d/4d metal oxides containing precious metals through detailed structure refinements using high-resolution neutron and X-ray diffraction data along with exploration of the resultant properties.
Oxides of 4d or 5d transition metals tend to show new topological phases due to significant spin-orbit...
Published January 1988. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Article 1: Behavior of Epoxy Injected Diagonally Cracked Full-Scale CRC Deck-Girders.
Many cast-in place reinforced concrete deck-girder bridges (RCDG) remain in the national inventory and exhibit diagonal cracking. Epoxy injection has been in use for several decades as a method for sealing diagonal cracks, but the effects on girder behavior...
Published June 1996. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Facultative/winter six-row malting barley is a distinct elite germplasm pool and a valuable resource that may prove useful in meeting the challenges of climate change. To preserve its diversity and make it accessible to the research and agricultural communities, the Oregon State University and University of Minnesota barley breeding programs...
Ankle injuries comprise more than 15% of all sports injuries worldwide. The efficacy of the ankle taping for injury prevention has long been under scrutiny as numerous studies have shown that tape rapidly loses its ability to constrain ankle motion with exercise. Consequently, ankle braces (orthoses) are being used with...
This is a listing of both PhD and Master's· theses relating to the areas of forestry issued during the period from July 1976 to June 1981. The
list is arranged first by state, then by college or university within each state. Authors of theses are arranged alphabetically under each of...
This paper adopts the hedonic price model to study the impact of attributes on beer prices in the U.S. beer market. The price of beer is modeled as a function of beer characteristics. Our primary purpose is to investigate the attributes that lead to premium beer prices. Understanding factors that...
This thesis examines archaeological material in order to explore gender and ethnicity issues concerning fur trade era families from a settlement in the Willamette Valley, Oregon. Ethnohistorical information consisting of traders journals and travelers observations, as well as documentation from the Hudson's Bay Company, Catholic church records, and genealogical information...
The purpose of this study was to better understand the relationship between selected academic factors and the persistence of GED recipients in community colleges in the state of Oregon. With this purpose in mind, the study addressed the following research question: Is there a relationship between selected academic variables and...
Land use regulation as a nonstructural method of flood
damage mitigation has proven to be a controversial measure due, among
other things, to suspected adverse impacts upon residential land values.
Little evidence, however, has been gathered to substantiate this claim.
This study attempts to analyze the relationship between flood plain...
The survey, commencing in May 2000, is the first broad based national recreational fishing survey of its kind in Australia. While primarily designed to provide biologic and fisher participant data, it provides a platform for the collection of data applicable to economic policy questions.
The survey methodology is based on...
An extensive review of the literature dealing with the role of
copper in nutrition has been made; much emphasis has particularly
been placed upon some of the "comparative" aspects of copper metabolism
in various species.
A study of the comparative copper metabolism of three strains
of rats and of golden...
An investigation of the correlation between a number of behavioral,
morphological and physiological parameters and dominance status of male
Ring-necked Pheasants (Phasianus colchicus) was undertaken. Dominant
males performed significantly more aggressive behaviors than
subordinates and a higher proportion of these behaviors was directed
toward distantly ranked subordinates. Animals could also...
The Bureau of Land Managements (BLM) Emergency Fire Rehabilitation (EFR) policy was developed in 1985 to encourage protection of sites from soil erosion and to minimize potential changes in vegetation communities that may result from the dominance of weedy species. To achieve the goals of EFR policy, managers often used...
This investigation was initiated in an attempt to delineate
some factors affecting the adsorption of poliovirus to soil particles
in seawater. The results could have significance in the development
of assay procedures for viral contaminants in natural waters.
A sample of marine sediment, obtained from an estuary near
Purdy, Washington,...
A series of field experiments was established in 1978, 1979, and 1980 on Lower Klamath Lake where Mn deficiency of oats had been observed in previous years. The pH of the soils ranged from 7.6 to 8.3 and the organic matter content was between 17 and 19%. The objectives of...
High resolution land use/land cover information from
stream riparian areas is useful in understanding instream
biotic assemblages, and is often not available for
geographical research. A classification system was developed
which provides the types of information about the riparian
buffer thought to be important in providing good habitat for,
or...
Published March 1951. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The purpose of this study was to investigate the effect of trained hearing peer
tutors on the physical activity levels of deaf students in integrated elementary
physical education classes. This study utilized a single subject multiple
baseline design across subjects.
Eight deaf 4th and 5th grade students and eight hearing...
The Seventh Annual James A. Vomocil Water Quality Conference was planned after three topics had been selected as being of particular interest. Wetlands, Best Management Practices, and Riparian Zone Effectiveness were the topics. Speakers were invited who by virtue of their training, their experience, or their work assignment had insights...
Forest disturbances, such as wildfires, pine beetle outbreaks, and floods are important features of many landscapes and ecosystems. Many disturbances are increasing in size, frequency, and intensity due to changing climates and land management decisions. The changing ecological and aesthetic conditions following a disturbance can lead to negative short- and...
........................................................... 240
K. Ranges of means and standard deviations across fires for the outcome
variable and the
Aims:
While lateral root mass is readily detectable with ground penetrating radar (GPR), the roots beneath a tree (below-stump) and overlapping lateral roots near large trees are problematic for surface-based antennas operated in reflection mode. We sought to determine if tree size (DBH) effects GPR root detection proximal to longleaf...
Traditional risk-based analysis for levee planning focuses primarily on overtopping failure. Although many levees fail before overtopping, few planning studies explicitly include intermediate geotechnical failures in flood risk analysis. This study develops a risk-based model for two simplified levee failure modes: overtopping failure and overall intermediate geotechnical failure from through-seepage,...
The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure on hepatic
pyruvate carboxylase (PC) gene expression were investigated in C57BL/6J Ah[superscipt b/b male
mice. A dose-dependent reduction of PC levels and activity occurred in animals given a
single intraperitoneal dose of TCDD in a corn oil carrier. The dose ranged from 1 to...
Dietary cyclopropenoid fatty acids (CPFA) have long
been known to cause pronounced physiological disorders in
both farm and laboratory animals. Past work has shown
CPFA to be a powerful promoter of carcinogenesis in trout,
rats and mice. Sterculic and malvalic acids (CPFA's) are
found in seed lipids of plants from...
The objective of this thesis is to provide a predictive model for the archaeological investigation of the first farmsteads in the Pacific Northwest, established in the early- and mid-nineteenth century by Canadien and Métis families retiring from their service in the fur trade. Past studies of this population have either...
Every activity of a pharmacy is related in some measure to the financial results of the business. The need for sound financial management permeates almost every phase of pharmacy operations. Pharmacy bankruptcies were at a 20-year high in 1961. The lack of specific literature on pharmacy financial management, especially at...
In endurance-trained men, an acute bout of exercise is shown to suppress post-exercise appetite, yet limited research has examined this response in women. The purpose of this study was to investigate the effect of exercise intensity on appetite and gut hormone responses in endurance-trained women. Highly-trained women (n = 15,...
El Niflo and La Nifia are oceanographic and atmospheric phenomena that have been
catalogued for well over a centuly. In El Nifio years, Peru's otherwise thy west coast is
subjected to torrential rainfall. Higher ocean temperatures off the coast are deemed the
culprit. Attempts to quantify this began in the...
The stability and value of transgenic pest resistance for promoting tree growth are poorly understood. These data are
essential for determining if such trees could be beneficial to commercial growers in the face of substantial regulatory and
marketing costs. We investigated growth and insect resistance in hybrid poplar expressing the...
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., Macdonald, P., Oguchi, T., Pasquali, G., Pearson, L., Peter, G.,
Quemada, H., Séguin, A., Tattersall, K
In a recent survey, it was observed that many woody plant species grown in Pacific Northwest nurseries exhibited disease symptoms typical of a bacterial infection and Pseudomonas syringae was commonly isolated from these tissues. The distribution of the ice nucleation phenotype among P. syringae strains recovered from these infected woody...
Three studies were designed to evaluate the promoting
effect of cyclopropenoid fatty acids (CPFA) on avian myeloblastosis
virus (AMV) infection in White Leghorn chickens.
In the first study effects on growth parameters, blood serum
and erythrocyte lipid composition of White Leghorn chickens
were investigated at 100 ppm and 300 ppm...
This paper sought to understand the extent to which, and how individuals use personal or collective language when asked to articulate sense of place from a collective perspective. Understanding a collective sense of place could illuminate place-based connections in natural resource industries, where it is as groups or as institutions...
Targhee Russet is a darker-skinned russet potato variety that has shown higher total and marketable yields than Russet Burbank in most yield trials conducted in the western United States. A major strength of Targhee Russet is resistance to tuber soft rot, and it also has moderate resistance to common scab,...
Mountain Gem Russet is a potato variety notable for having both high early and full-season yields of oblong-long, medium-russeted tubers with higher protein content than those of standard potato varieties. Mountain Gem Russet has greater resistance to soft rot, tuber late blight, growth cracks and second growth than Russet Burbank....
Pacific lampreys (Lampetra tridentata) have declined in abundance in the Columbia River Basin. Although, the reasons for the decline are unclear, we suggest that development of hydroelectric dams and habitat alterations in tributaries as the main causes. The available knowledge of life history of Pacific lampreys and status from dam...
I experimentally test the hypothesis that the potential for selfing
increases with plant size in Mertensia ciliata (Boraginaceae), a self-compatible,
profusely-flowering perennial. This follows from the
premises that 1) pollen dispersal by pollinators between flowers is
limited, and 2) individual pollinators, in this study bumblebees, will
visit more flowers per...
Two standardized land classification systems designed for use
with remote sensor data were studied comparatively. One of tile
classification systems is proposed for review and testing in U. S. 0.S.
Circular 671 (Legend I) (Anderson et al., 1972); the other is a hierarchial
legend system in use since 1968 (Legend...