This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.chemmater.5b03128
Full Text:
Materials. doi:10.1021/acs.chemmater.5b03128
10.1021/acs.chemmater.5b03128
American Chemical Society
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.est.5b00499
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&
Technology. Advance online publication. doi:10.1021/acs.est.5b00499
10.1021/acs.est.5b00499
American
This is the author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.chemmater.5b03128
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.est.5b00499
Image-guided phototherapy is extensively considered as a promising therapy for cancer treatment. To enhance translational potential of this modality, we developed a single agent-based biocompatible nanoplatform that provides both real time near-infrared (NIR) fluorescence imaging and combinatorial phototherapy with dual photothermal and photodynamic therapeutic mechanisms. The developed theranostic nanoplatform consists...
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by the American Chemical Society and can be found at: https://doi.org/10.1021/acs.est.5b00499
Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight
polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by
the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human
carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
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/10.1021/tx5003996 | Chem. Res. Toxicol. 2015, 28, 126−134
component of food from a French market
Dibenzo(def,p)chrysene (DBC), (also known as dibenzo[a,l]pyrene), is a high molecular weight
polycyclic aromatic hydrocarbon (PAH) found in the environment, including food, produced by
the incomplete combustion of hydrocarbons. DBC, classified by IARC as a 2A probable human
carcinogen, has a relative potency factor (RPF) in animal cancer models 30-fold higher...
Full Text:
.
Chemical Research in Toxicology. doi:10.1021/tx5003996
10.1021/tx5003996
American Chemical Society
Fluorescent proteins (FPs) are luminescent biomolecules that emit characteristic hues upon irradiation. A group of calmodulin (CaM)-green FP (GFP) chimeras have been previously engineered to enable the optical detection of calcium ions (Ca²⁺). We investigate one of these genetically encoded Ca²⁺ biosensors for optical imaging (GECOs), GEM-GECO1, which fluoresces green...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
The general theme of this dissertation is the development of new analytical sensors to quantitatively study biological and environmental samples in aqueous and non-aqueous environments. A platinum ultramicroelectrode (UME) and a unique carbon-based pH microprobe were used to design a new SECM-based electrochemical bioassay. The Pt UME was used to...
Expression Atlas (http://www.ebi.ac.uk/gxa) provides information about gene and protein expression in animal and plant samples of different cell types, organism parts, developmental stages, diseases and other conditions. It consists of selected microarray and RNA-sequencing studies from ArrayExpress, which have been manually curated, annotated with ontology terms, checked for high quality...
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identification
with Mascot Percolator. Journal of proteome research 2009;8;6;3176-81, DOI:
10.1021/pr800982s
The detection of biomolecules is critical for clinical diagnostics but requires specialty labor and high cost. The use of microfluidic paper-based analytical devices (µPADs) for bioassays is simpler and cheaper but has low sensitivity. Improved immobilization of antibodies onto cellulose is demonstrated through surface functionalization with APTES and glutaraldehyde. The...
Reoxidation and mobilization of previously reduced and immobilized uranium by dissolved-phase oxidants poses a significant challenge for remediating uranium-contaminated groundwater. Preferential oxidation of reduced sulfur-bearing species, as opposed to reduced uranium-bearing species, has been demonstrated to limit the mobility of uranium at the laboratory scale yet field-scale investigations are lacking....
The Fukushima Daiichi power station released
several radionuclides into the Pacific following the March 2011
earthquake and tsunami. A total of 26 Pacific albacore (Thunnus
alalunga) caught off the Pacific Northwest U.S. coast between
2008 and 2012 were analyzed for ¹³⁷Cs and Fukushima-attributed
¹³⁴Cs. Both 2011 (2 of 2) and...
Femtosecond stimulated Raman spectroscopy (FSRS) is a powerful ultrafast technique which can track photoinduced excited state structural events on femtosecond (fs) to picosecond (ps) timescales. In addition to high temporal and spectral resolutions, FSRS provides a broad spectral window from ca. 100—2000 cm-1 for detection, enabling the direct mapping of...
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Low-dimensional electronic materials offer a platform to observe biological processes with unprecedented spatial and temporal resolution. Carbon nanotubes (CNTs) are the closest physical analog to an ideal 1D system and can be scaled and integrated into multiplexed electronic circuitry. The molecular structure of a CNT is also biocompatible, making them...
Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
Tooth decay in the form of dental caries and cavities is estimated to be among the most common health conditions globally, with treatment of these oral diseases resulting in a massive, world-wide economic burden. The cause of this demineralization of teeth is rooted in the action of complex microbial biofilms...
Air-cathode fabrication is currently a key factor that hinders the scaling up of microbial fuel cell (MFC) technology. A new type of cathode material that contains porous polyethylene (PE) sheet and a blended activated carbon (AC) and highly conductive carbon back (CB) layer was developed for the first time. The...
The current work sought to develop predictive
models between time-weighted average polycyclic aromatic
hydrocarbon (PAH) concentrations in the freely dissolved
phase and those present in resident aquatic organisms. We
deployed semipermeable membrane passive sampling devices
(SPMDs) and collected resident crayfish (Pacifastacus
leniusculus) at nine locations within and outside of the...
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), 6291-6299. doi:10.1021/es5000534
10.1021/es5000534
American Chemical Society
Version of Record
http
We describe continental-scale increases in lake and stream total phosphorus (TP) concentrations, identified through periodic probability surveys of thousands of water bodies in the conterminous U.S. The increases, observed over the period 2000–2014 were most notable in sites in relatively undisturbed catchments and where TP was initially low (e.g., less...
In this paper, we report a unique property of inactivating Gram-positive/negative bacteria in the dark via apatite-covered Ag/AgBr/TiO2 nanocomposites (AAAT). We demonstrate that the inactivation mechanism is bacteriostatic based on the cellular integrity and motility of bacteria, low toxicity and high durability of AAAT. From straight observations, the catalytic loading...
Tropical fruit aromas are prominent in wines like Sauvignon Blanc, one of the most abundant white wines in the United States. With high consumer interest for these aromas, it has become increasingly important to understand the factors that influence the desired tropical fruit aromas in white wines. Understanding the causes...
Aqueous, two-phase systems (ATPSs) may form upon mixing two solutions of independently water-soluble compounds. Many separation, purification, and extraction processes rely on ATPSs. Predicting the miscibility of solutions can accelerate and reduce the cost of the discovery of new ATPSs for these applications. Whereas previous machine learning approaches to ATPS...
The unique capability of carbon-based ion-selective electrode (ISE) to perform highly sensitive anodic stripping voltammetry, while maintaining all the properties of an ISE, is demonstrated in terms of sensitivity, detection limit, response time and selectivity. Square wave anodic stripping voltammetry involves deposition and dissolution steps of metal ions, which means...
The phases of transition alumina are scientifically interesting due to their high specific surface area, favorable acid/ base characteristics, and chemical and hydrothermal stability which make this metallic oxide a prime candidate for use as a support for metallic nanoparticles (NPs) in heterocatalysis. Interactions at alumina/Pt interfaces are important for...
The discovery of a brilliant-blue color upon the introduction of Mn³⁺
to the trigonal-bipyramidal (TBP) sites in YInO₃ has led to a search for other hosts
for Mn³⁺ in TBP coordination. An obvious choice would be YAlO₃. This compound,
which has only been prepared through a citrate precursor route, has...
Full Text:
:10.1021/ic502027k
10.1021/ic502027k
American Chemical Society
Version of Record
http
Liquid transportation fuels require costly and time-consuming tests to characterize metrics, such as Research Octane Number (RON) for gasoline. If fuel sale restrictions requiring use of standard Cooperative Fuel Research (CFR) testing procedures do not apply, these tests may be avoided by using multivariate statistical models to predict RON and...
A series of new ternary graphite intercalation compounds (GICs) containing alkaline earth metal cations (M = Mg, Ca, Sr, Ba) and ethylenediamine (en) are reported. These GICs are deep blue to green in color and can be prepared as phase-pure compounds by the direct reaction of graphite powder with the...
Historically, 3M aqueous film-forming foams (AFFFs) were released at U.S. military and civilian sites to extinguish hydrocarbon-based fuel fires. To date, only C₄–C₁₀ homologues of the perfluoroalkyl sulfonic acids (PFSAs) are documented in 3M AFFFs. Perfluoroethanesulfonate (PFEtS) and perfluoropropanesulfonate (PFPrS), two ultra-short-chain PFSAs, were discovered by liquid chromatography (LC) quadrupole...
The relative influences of trans-Pacific and regional atmospheric transport on measured concentrations of polycyclic aromatic hydrocarbons (PAHs), PAH derivatives [Nitro- (NPAH) and Oxy-(OPAH)], organic carbon (OC), and Particulate Matter (PM) less than 2.5 μm in diameter (PM₂.₅) were investigated in the Pacific Northwest, USA in 2010-2011. Ambient high volume PM₂.₅...
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Science &
Technology, 49(23), 13807-13816. doi:10.1021/acs.est.5b00800
10.1021/acs.est.5b00800
American
Conspectus:
The flexibility, complexity, and size of contemporary organocatalytic transformations pose interesting and powerful opportunities to computational and experimental chemists alike. In this Account, we disclose our recent computational investigations of three branches of organocatalysis in which nonbonding interactions, such as C–H···O/N interactions, play a crucial role in the organization...
Recognizing the importance of methane hydrate research and the need for a coordinated effort, the United States Congress enacted the Methane Hydrate Research and Development Act of 2000. At the same time, the Ministry of International Trade and Industry in Japan launched a research program to develop plans for a...
Polyoxometalates (POMs) are anions consisting of three or more early transition metals ™ (Gr V and VI) oxoanions (in their highest oxidation state) linked together by a shared oxygen bond to form a 3D framework. Polyoxometalates (POMs) are a rapidly growing class of metal oxo clusters with a wide range...
Nerve damage during surgery is a common morbidity experienced by patients that leaves them with chronic pain and/or loss of function. Currently, no clinically approved imaging technique exists to enhance nerve visualization in the operating room. Fluorescence image-guided surgery has gained in popularity and clinical acceptance over the past decade...
The ability of plants and microorganisms to take up organic nitrogen in the form of free amino acids and oligopeptides has received increasing attention over the last two decades, yet the mechanisms for the formation of such compounds in soil environments remain poorly understood. We used Nuclear Magnetic Resonance (NMR)...
Photovoltaic cells have long been a desirable alternative to the consumption of fossil fuels, but current manufacturing practices suffer from poor energy efficiency, large carbon footprints, low material utilization, and high processing temperatures. A critical step in production of thin film CdTe and CuInSe₂ solar cells is the chemical bath...
Biofortification of staple crops like potato via breeding is an attractive strategy to reduce human micronutrient deficiencies. A prerequisite is metabolic phenotyping of genetically diverse material which can potentially be used as parents in breeding programs. Thus, the natural genetic diversity of thiamin and folate contents was investigated in indigenous...
We report the use of MIL-120 as a water-stable and cost-effective metal-organic framework (MOF) for selectively capturing CO₂ from wet flue gas. Synthesized using inexpensive and environmentally benign reagents in water, MIL-120 possesses one-dimensional pores decorated with hydroxyl-bridged Al(III) ions and benzene rings with an interstitial spacing of 4.78 Å....
Solvent extraction is an integral chemical and biochemical separation process that is drastically intensified in microfluidic systems. A novel high-throughput micro-separator was additively manufactured for the intensification of liquid–liquid separation. The micro-posts array within the flow plate generated a capillary pressure gradient on the non-wetting organic phase, enabling continuous, membrane-free,...
The aerobic biotransformation pathways of 4:2, 6:2, and 8:2 fluorotelomer thioether amido sulfonate (FtTAoS) were characterized by determining the fate of the compounds in soil and medium microcosms amended with an aqueous film-forming foam (AFFF) solution. The biotransformation of FtTAoS occurred in live microcosms over approximately 40 days and produced...
Full Text:
:10.1021/acs.est.5b01219
10.1021/acs.est.5b01219
American Chemical Society
Version of Record
http
Solid-state ¹H magic-angle spinning (MAS) NMR was used to investigate local proton environments in anhydrous [UO₂(OH)₂] (α-UOH) and hydrated uranyl hydroxide [(UO₂)₄O(OH₆ 6·5H₂O (metaschoepite). For the metaschoepite material, proton resonances of the μ₂-OH hydroxyl and interlayer waters were resolved, with two-dimensional (2D) double-quantum (DQ) ¹H–¹H NMR correlation experiments revealing strong...
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Chemical Society 10675 DOI: 10.1021/acs.jpcc.6b02692
J. Phys. Chem. C 2016, 120, 10675−10685
oxygen
Self-assembly of recombinant proteins within the biosilica of living diatoms represents a means to construct functional materials in a reproducible and scalable manner that will enable applications that harness the inherent specificities of proteins to sense and respond to environmental cues. Here we describe the use of a silaffin-derived lysine-rich...
In this work, colloidal PbSe quantum dots (QDs) are shown to be synthesized in a controlled manner by changing the growth time and reaction temperature in a microwave synthesis method. It is explained why quantum dots make such a unique material to create electronic devices and the specific benefits that...
Driven by major scientific advances in analytical methods, biomonitoring, computation, and a newly articulated vision for a greater impact in public health, the field of exposure science is undergoing a rapid transition from a field of observation to a field of prediction. Deployment of an organizational and predictive framework for...
The diatom Thalassiosira pseudonana was genetically modified to express biosilica-targeted fusion proteins comprising either enhanced green fluorescent protein (EGFP) or single chain antibodies engineered with a tetracysteine tagging sequence. Of interest were the site specific binding of (1) the fluorescent biarsenical probe AsCy3 and AsCy3e to the tetracysteine tagged fusion...