Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
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. Bhat, Jeff M. Blaney, Evan Bolton, Gerard Bricogne, David
Brown, StephenK. Burley, David A. Case, Kirk
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
Full Text:
Bolton,9 Gerard Bricogne,10 David Brown,11,12 StephenK. Burley,5,6,13,* David A. Case,6
Kirk L. Clark
Crystallographic studies of ligands bound to biological macromolecules (proteins and nucleic acids) represent an important source of information concerning drug-target interactions, providing atomic level insights into the physical chemistry of complex formation between macromolecules and ligands. Of the more than 115,000 entries extant in the Protein Data Bank (PDB) archive,...
The preservation of land, such as wetlands and agricultural
lands, is often pursued through traditional methods such as zoning or
eminent domain. Transferable Development Rights provides a different
approach to the preservation of land by allowing the sale and transfer
of development rights from land to be protected to land...
The influence of overstory openness on the reproductive
ecology of Pacific yew (Taxus brevifolia Nutt.) was
investigated on 4 sites in western Oregon over 2 years. The
breeding system of T. brevifolia was found to deviate from
pure dioecy under a broad range of canopy and site
conditions. Production of...
Anchors resistant to tensile loads are commonly used in civil engineering practice. Anchors in the marine environment are most frequently used for the mooring of vessels. Only recently, with the expansion of the offshore industry, has the need to develop more reliable anchor systems become necessary. Embedded plate anchors are...
The use of electronic cigarettes (often referred to as vapes or e-cigs) has grown rapidly in the past decade. While these devices may not deliver the same level of carcinogens and toxicants as combustible cigarettes, they can deliver nicotine (a known developmental toxicant) as efficiently. Previous work suggests that, during...
The Soil Conditioning Index (SCI) aids the conservationist in designing crop rotations and residue management practices when low organic matter, poor soil tilt, and crusting problems are identified. The Natural Resources and Conservation Services (NRCS) field staff and others use the SCI as a qualitative tool during conservation planning. In...
The heritability of resistance to eastern filbert blight, caused by Anisogramma anomala, in European hazelnut (Corylus avellana) was evaluated in the progeny of seven cultivars crossed in 12 combinations. Progeny produced by crossing 'VR6-28' with three susceptible cultivars segregated 1:1 for complete resistance to eastern filbert blight. Histograms of disease...
Interactions between proteins and contact surfaces can have
important implications in the food industry. Such interactions
contribute to the course of fouling of membrane surfaces and they
appear to mediate bacterial and spore adhesion to some degree as
well. In addition to protein and solution properties, interfacial
behavior is strongly...
Flavin-containing monooxygenase (FMO) oxygenates drugs/xenobiotics containing a
soft nucleophile through a C4a hydroperoxy-FAD intermediate. Human FMOs 1, 2 and
3, expressed in Sf9 insect microsomes, released 30-50% of O₂ consumed as H₂O₂
upon addition of NADPH. Addition of substrate had little effect on H₂O₂ production.
Two common FMO2 (the major...
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Hydrogen Peroxide
Siddens, L. K., Krueger, S. K., Henderson, M. C., & Williams, D. E. (2014).
Mammalian
'Alba' (Reg. No. [CV-355, PI 672535]) is a winter, six-row barley released by the Oregon Agricultural Experiment Station in 2012. The name “Alba” was chosen due to the bright and attractive appearance of the crop at maturity. In high rainfall environments, it has a notable yield advantage over check varieties...
Sulfur is one of the six elements required during the early stages of the evolution of life, and enzymes involved in sulfur transfer and oxidation are increasingly being recognized as potential drug targets for antimicrobials as well as for therapies for cancer, neurodegenerative and inflammatory diseases. Bacteria are able to...
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
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Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Douglas-fir (Pseudotsuga menziesii) has a wide distribution in North America and is one of the
tree species most widely distributed outside its natural range. The species has been introduced to
Europe, New Zealand, South America, and elsewhere around the world. At present, Douglas-fir
is an accepted and integral part of...
Full Text:
Douglas-fir
Denis P. Lavender and Richard K. Hermann
The
Responses to two cycles of mass selection for heading date,
followed by selfing or intermating, were studied in two diverse
winter wheat (Triticum aestivum L. em. Thell) crosses. Selection
was bidirectional, resulting in early and late populations for
each mating system, cycle, and cross. The influence of mass
selection for...
The sexually transmitted disease gonorrhea, caused by the Gram-negative bacterium and obligate human pathogen Neisseria gonorrhoeae, remains a significant health and economic burden worldwide. In the absence of a protective vaccine, antimicrobial agents are the only pharmacological intervention for patients with gonorrhea. However, due to the remarkable ability of gonococcus...
Published September 1978. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The cockpit is an environment in which many important tasks simultaneously
compete for pilot attention. Cockpit Task Management (CTM) is the process by
which pilots selectively attend to flight tasks in such a way as to safely and
effectively complete a flight. CTM has been categorized as a mental function...
Although the potato (Solanum tuberosum L.) is a global crop, few growing regions rival the high yields of the Columbia Basin of Eastern Oregon and Washington. Two research projects were conducted in Hermiston, OR to contribute to best management practices for the region. The first project evaluated the efficacy of...
Published February 1992. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Near-surface advanced argillic hydrothermal alteration zones, also referred to as lithocaps, are characterized by quartz, alunite, clays (pyrophyllite and kaolinite group minerals), and minor F-bearing aluminosilicates (i.e., topaz, zunyite, diaspore, and APS) that form where water-, SO2-, and HF-rich gas condenses into shallow groundwater, acidifies, and reacts with rocks. The...
The purpose of this study was to examine the experiences of foster alumni in community and technical colleges, with a focus on Washington State, using a qualitative research approach. Foster alumni may be considered a sub-set of first generation students, yet they have needs that extend beyond those of other...
This thesis involves analyses of 3₂-helices, a-helices and of the change in residual
entropy of a protein upon chemical modification. Part of the long-term goal of
understanding the formation, function and stability of proteins requires that all
conformations be accurately assigned and structurally understood. By a statistical
analysis of 258...
We evaluated effects of chemical fertilizer, spacing, and interplanted nitrogen-fixing trees on wood density and diameter growth of 15-year-old Eucalyptus saligna trees. The trees were grown in silvicultural trials established on former sugarcane land on the island of Hawaii. Elevation was 480 m, slopes were gentle, and annual rainfall averaged...
We have developed crown-gall resistant transgenic plants capable of suppressing Agrobacterium tumefaciens T-DNA oncogenes. Crown gall tumors result from overproduction of auxin and cytokinin in plant cells transformed by A. tumefaciens. High phytohormone levels result from expression of two auxin biosynthetic genes, tryptophan monooxygenase (iaaM) and indole acetamide hydrolase (iaaH),...
Plum pox virus (PPV) is a member of the Potyvirus genus that, in nature, infects trees of the Prunus genus.
Although PPV infects systemically several species of the Nicotiana genus, such as N. clevelandii and N.
benthamiana, and replicates in the inoculated leaves of N. tabacum, it is unable to...
Instream flow protection in western prior appropriation states is a relatively new phenomenon.
Integrating instream flow protection measures with the older water law has been accomplished with varying
degrees of success. Idaho relies on appropriation of unappropriated water by the Idaho Water Resource Board
for protection of instream flows. Idaho's...
The epiphytic lichen Letharia vulpina has been commonly sampled in-situ for nitrogen (N) deposition biomonitoring studies but has never before been transplanted for this purpose. In the high-elevation wilderness areas of southern California Letharia vulpina is generally uncommon, making in-situ sampling difficult. In this study, we compared thallus N accumulation...
Academic success is a salient domain of youth development and is related to positive lifelong outcomes among youth in foster care. However, youth in foster care experience compounding adversities, including maltreatment and foster care placement itself, which put them at risk of academic disengagement and underachievement. Despite these adversities, academic...
This manuscript describes the role of non-classical hydrogen bonds (NCHBs), specifically C–H···O interactions, in modern synthetic organic transformations. Our goal is to point out the seminal examples where C–H···O interactions have been invoked as a key stereocontrolling element and to provide predictive value in recognizing future and/or potential C–H···O interactions...
The "Framework for Determining the Suitability of Undeveloped
Land for Use as Cropland" is a decision-making format to assist private
and governmental agency decision makers in categorizing undeveloped
lands, which have been identified as having potential for conversion
to cropland, as to their suitability for use as cropland. The
Framework...
Published June 1998. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
The objective of this study was to compare the effects on eating behavior,
lipids, lipoproteins, lipid peroxidation, and glycemic control in women with type 2
diabetes of a high-monounsaturated fat diet (HM) compared to a high-carbohydrate
diet (HC).
In an outpatient feeding study, ten hypertriglyceridemic postmenopausal type
2 diabetic women...
This thesis consists of three manuscripts addressing separate components of barley breeding, plus an introduction and a conclusion summarizing the status of barley in the Pacific Northwest, plus the implications of the research presented in this thesis. In the first manuscript, a package written for the statistical software "R" that...
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, Dr.
Don Obert, Dr. Kevin P. Smith, and Dr. Stephen Ullrich contributed germplasm that was
Published April 1993. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalog
Butter has long been the premium choice for producing pastries such as Danish and croissants. Its inclusion has consistently delivered characteristically light and airy crumbs with beautifully flaky crust. Once considered a delicacy, pastries have now become innocuous in our everyday lives. Once requiring a skillful hand to sculpt and...
Cyclopropenoid fatty acids (CPFA) are natural components of
cottonseed oil, a major food oil in the United States. The ability of
CPFA to cause abnormal biochemical and physiological effects when
fed to laboratory and farm animals has prompted an investigation of
their effects on mice.
Between 0.05 and 0.55% CPFA...
Peppermint, Mentha piperita 'Black Mitcham' was established as a host for tomato
spotted wilt virus-impatiens serotype (TSWV-I). TSWV-I infection of peppermint,
initially observed in a research greenhouse (Corvallis, OR), included stunting and
downward curling of leaves accompanied by bronzing, and occasionally tip necrosis.
Young leaves appeared either symptomless, deformed, or...