The dipyridophenazine (dppz) based ruthenium polypyridyl complexes are known as molecular ‘light-switches’ for DNA. This property is poised to serve in diagnostic and therapeutic applications, but the poor cellular uptake restricts their use in live cells. Herein, we show that the cellular uptake, and more interestingly and surprisingly, the nuclear...
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information (
and crystallographic data in CIF or
10.1039/c5sc03796d
Cite this: Chem. Sci., 2016, 7, 4016
The study of the effects of diethyldithiocarbamate (DEDTC) in some diseases is in focus for many years. However, DEDTC is a metal chelator that can present neurotoxicity as side effects. Here we investigate the effect of DEDTC on brain Zinc (Zn) content and behavior. To address this issue we used...
A series of combined measurements was made at the Naval Air Station North Island (NASNI) Installation Restoration Site 5, Unit 2 during July and August 2013. Combined measurements included CO₂ respiration rate, CO₂ radiocarbon content to estimate chlorinated hydrocarbon (CH) mineralization and a zone of influence (ZOI) model. CO₂ was...
Porous substrates transport fluid via capillary action and can be inexpensive, making them ideal for field-use sensors. Direct wax printing is one of the most commonly used fabrication methods to define fluid paths in standard substrates like cellulose and nitrocellulose. However, direct wax printing is not possible for flexible materials...
ZIF-8, a zeolitic imidazolate framework that consists of zinc ions and imidazolate linkers, is of great interest due to its simple synthesis methods, low-cost raw materials, chemical and thermal stability, as well as its stability in moist environments. Furthermore, due to its unique structure, it contains well-defined pores that have...
We demonstrate a novel synthetic route to fabricate a one-dimensional
peapod-like Sb@C structure with disperse Sb
submicron-particles encapsulated in carbon submicron-tubes.
The synthetic route may well serve as a general methodology
for fabricating carbon/metallic fine structures by thermally
reducing their carbon-coated metal oxide composites.
Acenes larger than pentacene are predicted to possess enticing electronic properties, but are insoluble and prone to rapid decomposition. Utilizing a combination of functionalization strategies, we present stable, solution processable hexacenes and an evaluation of their hole and electron transport properties.
Plastic pollution is an ever-increasing environmental threat. As large-scale plastics break down to form nanoscale plastics, it is essential to investigate their effects on freshwater ecosystems. With many plastic nanoparticle (NP) studies favoring the effects of common polystyrene (PS) plastics, a gap is formed for other common plastic types like...
NMR spectroscopy is the go-to technique for determining the solution structures of organic,
organometallic, and even macromolecular species. However, structure determination of nanoscale
aqueous inorganic clusters by NMR spectroscopy remains an unexplored territory. The few hydroxobridged
inorganic species well characterized by ¹H Nuclear Magnetic Resonance spectroscopy (¹H-NMR)
do not provide...
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≤ x ≤ 6) clusters by
¹H-NMR and QM computations. Chemical Science, 6(7), 4071-4085.
doi:10.1039
This study describes the combined experimental and computational elucidation of the mechanism and
origins of stereoselectivities in the NHC-catalyzed dynamic kinetic resolution (DKR) of α-substituted-β-ketoesters. Density functional theory computations reveal that the NHC-catalyzed DKR proceeds by two
mechanisms, depending on the stereochemistry around the forming bond: 1) a concerted, asynchronous...
A low-voltage plateau at ∼0.3 V is discovered during the deep sodiation of Na₃V₂(PO₄)₃ by combined computational and experimental studies. This new low-voltage plateau doubles the sodiation capacity of Na₃V₂(PO₄)₃, thus turning it into a promising anode for Na-ion batteries.
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-ion batteries. Chemical Communications, 51(29), 6381-6383.
doi:10.1039/c5cc00944h
10.1039/C5CC00944H
The reaction conditions for the synthesis of Cu-BTC (BTC = benzene-1,3,5-tricarboxylic acid) were elucidated using a continuous-flow microreactor-assisted solvothermal system to achieve crystal size and phase control. A high-rate synthesis of Cu-BTC metal-organic frameworks with BET surface area of more than 1600 m²/g (Langmuir surface area of more than 2000...
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:10.1039/c3cc46049e
10.1039/c3cc46049e
Royal Society of Chemistry
Accepted Manuscript
http
A novel method of copper indium diselenide nanoparticle
(CuInSe₂ NP) synthesis using a two-step, continuous flow,
solar microreactor is reported here. This method allows for
exceedingly fast heating and short reaction times using only
radiative heat transfer from simulated, concentrated solar
radiation. Chalcopyrite and sphalerite CuInSe₂ phases have
both been...
Solvent extraction is an integral chemical and biochemical separation process that is drastically intensified in microfluidic systems. A novel high-throughput micro-separator was additively manufactured for the intensification of liquid–liquid separation. The micro-posts array within the flow plate generated a capillary pressure gradient on the non-wetting organic phase, enabling continuous, membrane-free,...
Desferrioxamine B (DFOB) was reversibly and covalently conjugated to polystyrene microspheres via N-succinimidyl 3-(2-pyridyldithio)propionate (SPDP) crosslinker. DFOB retained post-immobilization activity with at least 89% able to bind Fe(III)-citrate under pH 7.4 and a citrate:iron molar ratio = 100:1. Comparing iron capture by DFOB-activated beads and sulfhydryl (−SH) control beads demonstrated...
A simple Janus-type membrane-based wicking microfluidic device fabricated on a polycaprolactone-filled glass microfiber membrane enables separation and collection of blood plasma or serum from whole blood. This device bridges the wicking and cut-capillary-based solution transport mechanisms in a single membrane. The initial portion of the device is fabricated using selective...
Combined plasmonic nanocrystals and metal–organic framework
thin-films are fabricated for sensing gases in the near-infrared
range. This nanocomposite thin-film shows a highly sensitive response
in near-infrared absorption, which is attributed to preconcentration
of gas molecules in metal–organic framework pores causing close
proximity to the electromagnetic fields at the plasmonic nanocrystal...
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Chemistry
C, 3(12), 2763-2767. doi:10.1039/C4TC02846E
10.1039/C4TC02846E
Royal Society of Chemistry
Small-angle X-ray scattering (SAXS) studies of aqueous [Ta₆O₁₉]⁸⁻
compared to prior studies of aqueous [Nb₆O₁₉]⁸⁻ reveals key
differences in behaviour, which is likely at the root of the difficultly
in developing polyoxotantalate chemistry. Specifically, where
contact ion-pairing dominates between [Nb₆O₁₉]⁸⁻ and its
counterions, solvent-separated ion-pairing between [Ta₆O₁₉]⁸⁻
and its counterions...
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and Nb polyoxometalates. Dalton Transactions,
43(41), 15295-15299. doi:10.1039/C4DT02394C
10.1039
Despite the considerable advances of deposition technologies, it remains a significant challenge to form conformal deposition on surface of nanoporous carbons. Here, we introduce a new ambient hydrolysis deposition method that employs and controls pre-adsorbed water vapor on nanoporous carbons to define the deposition of TiO₂. We converted the deposited...
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this: DOI: 10.1039/x0xx00000x
Received 00th January 2012,
Accepted 00th January 2012
DOI: 10.1039
TAML activators promise a novel water treatment approach
by efficiently catalysing peroxide-based degradation of
chemicals of high concern at environmental concentrations.
Green design ethics demands an exploration of TAML
toxicity. Exposure to high concentrations of certain activators
caused adverse effects in zebrafish. At typical TAML
operational concentrations, development was not...
We, for the first time, employ magnesiothermic reaction to convert microwave-irradiated graphite oxide to pure graphene. The magnesiothermic reaction raises the carbon to oxygen atomic ratio from 22.2 to 165.7 and maintains a high surface area. The new strategy demonstrates an efficient method for obtaining highly pure graphene materials.
Environmental archives provide records of natural and anthropogenic variation in the environment at different temporal and spatial scales. Lead (Pb) concentrations and isotopic ratios are useful tracers of anthropogenic emissions from industrial activities including mining, smelting, and leaded gasoline use, however, methods of measuring Pb are largely limited in low...
Naturally occurring assemblies, such as DNA and proteins, utilize intermolecular forces (i.e H-bonding and van der Waals) to assemble. Utilizing these electrostatic interactions has only just started in the past five decades to be a tool used in synthetic chemistry in what is known as supramolecular chemistry. Supramolecular chemistry has...
The development of simple, rapid, and sensitive methods for thiophenol detection is of great importance in various fields, including environmental monitoring and food quality. Here, we present a novel approach for the colorimetric detection of thiophenols using gold nanoparticles (AuNPs) as the sensing platform. AuNPs aggregate in the presence of...
Restricted rotations of chemical bonds can lead to the presence of persistent conformational chirality in molecules 10 lacking stereocenters. We report the development of first-ofa- kind predictive rules that enable identification of conformational chirality and prediction of racemization barriers in the diarylether heptanoid (DAEH) natural products that do not possess...
We report the use of MIL-120 as a water-stable and cost-effective metal-organic framework (MOF) for selectively capturing CO₂ from wet flue gas. Synthesized using inexpensive and environmentally benign reagents in water, MIL-120 possesses one-dimensional pores decorated with hydroxyl-bridged Al(III) ions and benzene rings with an interstitial spacing of 4.78 Å....
Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Air-cathode fabrication is currently a key factor that hinders the scaling up of microbial fuel cell (MFC) technology. A new type of cathode material that contains porous polyethylene (PE) sheet and a blended activated carbon (AC) and highly conductive carbon back (CB) layer was developed for the first time. The...
Polyoxometalates (POMs) are anions consisting of three or more early transition metals ™ (Gr V and VI) oxoanions (in their highest oxidation state) linked together by a shared oxygen bond to form a 3D framework. Polyoxometalates (POMs) are a rapidly growing class of metal oxo clusters with a wide range...
In Intense Pulsed Light (IPL) sintering, pulsed large-area visible light from a xenon lamp is absorbed by nanoparticle films or patterns and converted to heat, resulting in rapid sintering of the nanoparticles. This work experimentally characterizes IPL sintering of silver nanoparticle films. A newly observed turning point in the evolution...
Previous studies have reported that the metastable vaterite phase of calcium carbonate can be stabilized in solution by acidic additives. Here we demonstrate that vaterite can also be stabilized directly at surfaces by engineered peptides. Our data show that the mineralisation occurs in a 'self-templating' process where calcium ions restructure...
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mineralisation. See DOI: 10.1039/c5cc05830a
‡ Current address: Max Planck Institute of Colloids and Interfaces
The rare earth elements (REEs) with their systematically varying properties are powerful tracers of continental inputs, particle scavenging intensity and the oxidation state of seawater. However, their generally low (similar to pmol/kg) concentrations in seawater and fractionation potential during chemical treatment makes them difficult to measure. Here we report a...
The aggregation of 12 nm citrate-stabilized gold nanoparticles (cit-AuNPs) in the presence of four
different natural organic matter (NOM) isolates and a monovalent electrolyte (KCl) was evaluated using
time-resolved dynamic light scattering. All four NOM isolates stabilized the cit-AuNPs with respect to
aggregation. However, specific effects varied among the different...
A unique microreactor-assisted nanomaterial synthesis and printing process was studied for the fabrication of patterned metal oxide nanostructured thin films. The process uses a continuous flow microreactor to control and generate a reactive chemical flux that was transported to a patterned microfluidic channel. The microreactor-assisted nanomaterial synthesis process can generate...
Additive manufacturing has become a promising method for the fabrication of inexpensive, green, flexible sensors and electronics. Printed electronics on low- temperature substrates are very appealing for the flexible hybrid electronics market for their use in disposable and biocompatible electronic applications and in areas like packaging, wearables, and consumer electronics....
The metal organic framework, MOF-74(Ni), was synthesized in a continuous flow microwave-assisted reactor obtaining a high space-time yield (~90 g h⁻¹ L⁻¹) and 96.5% conversion of reagents. Separation of the nucleation and growth steps was performed by using uniform and rapid microwave heating to induce nucleation, which allowed a substantial...
The regiodivergent O- to C- or N-carboxyl transfer of pyrazolyl carbonates is described, with DMAP giving preferential N-carboxylation and triazolinylidenes promoting selective C-carboxylation (both with up to >99 : 1 regioselectivity). An enantioselective O- to C-carboxyl variant using NHC catalysis is demonstrated (up to 92% ee), while mechanistic and DFT studies outline...
The performance of an over 10 times larger microbial fuel cell (MFC) with double cloth electrode assembly (CEA) during 63 days of continuous operation demonstrates that the excellent performance of CEA-MFC can be further improved during scale-up. With a new separator material and U-shaped current collectors, the larger MFC produced...
Despite near unanimous opinion on the consequences of climate change by scientific community, the rate at which carbon is emitted into the atmosphere continues to increase. The need for a clean and sustainable source of energy is therefore one of humankind's most urgent challenges. Solar energy is the most abundant...
Aqueous, two-phase systems (ATPSs) may form upon mixing two solutions of independently water-soluble compounds. Many separation, purification, and extraction processes rely on ATPSs. Predicting the miscibility of solutions can accelerate and reduce the cost of the discovery of new ATPSs for these applications. Whereas previous machine learning approaches to ATPS...
In this work, metal-organic frameworks (MOFs) are computationally represented, generated, and evaluated. The organic linker molecules are represented as graphs and use graph grammars where the atoms are represented by nodes and the bonds are represented by arcs. The grammar rules that dictate the graph generation process work on the...
Magnetic materials can be used in modern soft robotics as a method for external stimulus actuation and motion control. By combining aspects of biology and mechanics, devices are fabricated to create a structure capable of complex movement. Applications that these devices are subject to can be broken down into four...
The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...
Nanoparticles (NPs) are generally defined as particles <100 nanometers (nm) in size in one dimension. Despite increasing industrial usage of TiO2 NPs in sunscreens, cosmetics, and water remediation little is known of their environmental behavior. The primary goal of this research was to develop a rapid method for determining the...
Polyoxometalates are a rapidly growing class of discrete metal oxide clusters with a wide range of applications including functional materials. These anionic clusters of the group V and VI transition metals are inexpensive and non-toxic. Within group V polyoxometalates, niobium and tantalum chemistry has been underdeveloped owing to their unique...
The rapid accumulation of plastic waste in landfill, waterways and oceans is becoming a critical problem, one that current recycling technologies are not capable of solving. Recent proposed approaches in the depolymerization of waste plastics employ an Olefin-Intermediate Process (OIP), where feedstocks like polyolefin plastics are ‘activated,’ producing an olefin...
Despite climate change requiring the cutback of fossil fuel consumption, the world continues to increase its energy demands each year. To meet the ambitious goals outlined during the Paris Agreement in 2015, which set a goal to limit global warming to 1.5°C [1], changes in energy production methods are necessary....
Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
Biohydrogen production via dark fermentation (DF) and microbial electrolysis cells (MEC) demonstrate great potential for sustainable hydrogen generation. In this study, DF and MEC were coupled as a hybrid reactor and evaluated using brewery wastewater. The effect of hydraulic retention time (HRT) and buffer concentration on reactor performance were assessed...
Microfluidics is an evolving field that focuses on the manipulation of small fluid volumes. Because of its micron-sized features, it is the basis for many lab-on-chip and point-of-care diagnostic devices. The devices are predominantly molded from polydimethylsiloxane (PDMS); however, production is a multi-hour or multi-day process that typically requires clean...
Assembly of nanocrystals is considered one of the most promising approaches to design nano-, microstructures, and complex mesoscopic architectures. A variety of strategies to induce nanocrystal assembly have been reported, including directed assembly methods that apply external forces to fabricate assembled structures. In this study ZnO nanocrystals were synthesized in...
Nanoscale polymers (including nanoplastics) are widely present through commerce and make their way into the environment. As the improper disposal of plastic waste leads to continued accumulation and degradation of plastic pollution, the presence of plastic particles less than 1 micron (μm) in size (nanoplastics) will increase. Heightened concern over...
Organic semiconductors are of interest for (opto)electronic applications due to their low cost, solution processability, and tunable properties. Natural product-derived organic pigments have attracted attention due to their extraordinary environmental stability and unexpectedly good optoelectronic performance, in spite of only partially conjugated molecular structures. Fungi-derived pigments are a naturally sourced,...
The general theme of this dissertation is the development of new analytical sensors to quantitatively study biological and environmental samples in aqueous and non-aqueous environments. A platinum ultramicroelectrode (UME) and a unique carbon-based pH microprobe were used to design a new SECM-based electrochemical bioassay. The Pt UME was used to...
Nanoparticles are a hugely diverse category of material that have a wide variety of biomedical applications, and developing tools for biological research with high cellular uptake is critical to their effective application. However, rarely is attention paid to the exact mechanism by which this is occurring, with most studies focusing...
In this work, a fully automated approach to synthesis Metal-Organic Frameworks is presented. We use graph to represent the structure of Metal-organic Frameworks and use graph grammars which are backbone rules and functional group rules to generate metal-organic framework. For a given parameter value of the user defined metal-organic framework,...
Paper-based assays for HIV diagnosis are cheap, portable, and require little to no skilled training, electricity, or expensive equipment to perform successfully. However, there is a need for tests with lower limits of detection (LOD) for diagnosing infection at the earliest stages. Effective labeling to increase signal-to-noise ratio is critical...
Ion pairs and solubility related to ion-pairing in water influence many processes in nature and in synthesis including efficient drug delivery, contaminant transport in the environment, and self-assembly of materials in water. Ion pairs are difficult to observe spectroscopically because they generally do not persist unless extreme solution conditions are...
Cobalt germanides have been widely studied as semiconductor contact materials, but recent theoretical studies suggest that they may also be excellent catalysts for methane steam reforming with stabilities and activities comparable to noble metal catalysts. In order to study the catalytic activity of cobalt germanides, it is critical to first...
The dipolar cylcoadditions of ortho-nitrophenyl alkynes with aryl nitrile oxides has been demonstrated. A range of substituents are tolerated on the alkyne. These reactions proceed with excellent levels of regioselectivity. Subsequent functionalization of the isoxazole scaffold has been demonstrated.
The continuous development of higher performing battery materials has emerged in parallel with the development of new manufacturing processes. Nanomaterials are one solution to addressing the cycling and performance challenges that limit existing battery cells. However, many of the methods used today for nanomaterial synthesis are high temperature batch methods...
Water bodies act as chemical data loggers that contain tens of thousands of molecules that represent the sum of the biological, chemical, and physical processes occurring within a watershed. We hypothesize that unique chemical signatures present within a water sample can be informative of upstream processes. By extracting non-polar organic...
Sporosarcina pasteurii is known to produce calcite or biocement in the presence of urea and Ca²⁺. Herein, we report the use of novel ultramicrosensors such as pH, Ca²⁺, and redox sensors, along with a scanning electrochemical microscope (SECM), to monitor a real-time, bacteria-mediated urea hydrolysis process and subsequent changes in...
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,
Accepted 27th February 2016
DOI: 10.1039/c6an00007j
www.rsc.org/analyst
Real-time monitoring of
Formation of cirrus clouds depends on the availability of ice nuclei to begin condensation of atmospheric water vapor. Although it is known that only a small fraction of atmospheric aerosols are efficient ice nuclei, the critical ingredients that make those aerosols so effective have not been established. We have determined...
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. 41, 6519 (2012).
doi:10.1039/c2cs35200a Medline
62. P. J. DeMott, An exploratory study of ice
While most biological materials are insulating in nature, efficient extracellular electron transfer is a critical property of biofilms associated with microbial electrochemical systems and several microorganisms are capable of establishing conductive aggregates and biofilms. Though construction of these conductive microbial networks is an intriguing and important phenomenon in both natural...
Immobilized proteins are integral components of a number of important technologies, including the principal component of many biosensors, as functional coatings in various implants, as catalysts is industrial biosynthesis, and as the building blocks of next-generation nanotechnologies. Despite their ubiquity, relatively little is known about the processes that shape immobilized...
The oxidation of carbon monoxide (CO) to carbon dioxide (CO2) is ubiquitous throughout many industrial processes and is a common probe reaction used to help understand catalytic systems in research settings. The reaction is essential in power generation and transportation exhaust gas treatment technologies to ensure environmental safety, because CO...
Flexible Electronics is a fast developing technology that is set to revamp and revolutionize conventional electronics through the development of devices that are easily conformable to surfaces of any arbitrary geometry. Such devices would have vast applications in areas where the rigidity of traditional silicon based electronics is undesirable, such...
We strategically modified the GFP core via chemical synthesis to make redder and brighter biomimetic fluorophores. Based on quantum calculations, solvatochromism analysis, and femtosecond Raman, we unveiled the additive effect of tuning the electronic ground and excited states, respectively, to achieve a dramatic emission redshift with a "double-donor-one-acceptor" structure.
In current nanotoxicology research, there is a lack of standardization in reporting of zebrafish exposure media and sonication practices. This lack of standardization in use and reporting methods has made reproducing nanoparticle (NP) toxicity results between labs a common issue. It is important to have a standardized way of reporting...
Modification of microbial electrolysis cells (MECs) by altering the sizes of the anode and the cathode, or their interaction with the liquid stream affects the performance of the MEC, but it remains difficult to quantify how much each change will contribute to the overall performance. Through this study, a method...
Listeria monocytogenes contamination continues to pose challenges for the food industry and there is demand for effective methods of food preservation and protection that can also be considered clean label. A promising source of antilisterial compounds may be sourced from bacteria that produce novel byproducts. Ribosomally synthesized and post-translationally modified...
In this dissertation, the structural properties, thermodynamics and defect behavior of amorphous metal oxides and polyoxometalates are studied. Amorphous metal oxides have many applications, most notably as a semiconducting material used as the active matrix of thin film transistors. Alas, the amorphous nature of these materials makes studying them rather...
Remote health monitoring tools have significant potential to revolutionize the current healthcare paradigm. Such tools could improve efficiencies in healthcare by alerting patients and doctors to abnormal health conditions in real time, shortening the time to diagnose and treat ailments. To meet these needs, we pursue the development of fabric-based...
Water electrolysis plays a pivotal role in achieving a green hydrogen economy by sourcing electricity from intermittent renewable sources. However, the efficiency of the electrolysis process is limited by the sluggish oxygen evolution reaction (OER) kinetics, whereas the kinetics of the hydrogen evolution reaction (HER) are more facile. This thesis...
Treated wood commodities disposed of in landfills contain chemicals that can migrate into the environment. Wood treatments such as ammoniacal copper zinc arsenate (ACZA) contain heavy metals which prevent the biological degradation of wood. These metals can migrate out of treated wood into soil or groundwater, posing environmental hazards. This...
The Jovanovic lab at Oregon State University (OSU) is developing iCore, a versatile blood processing platform which leverages microfluidic process intensification via increased mass transfer efficiency and decreased device footprint with the goal of creating a portable, wearable device. One application of iCore is for the treatment of hyperferremia resulting...
With Alzheimer’s disease being the most prominent form of dementia, finding potential treatments for the disease is imperative. This study explored the non-steroidal anti-inflammatory drug ibuprofen as a potential treatment to normalize the hyperactive N-methyl-d-aspartate receptor (NMDAR) within the 5xFAD mice early in the disease pathology before cognitive decline. Female...
Polyoxoniobates (PONbs) are attracting great attention in recent years due to its novelty as well as a variety of geometrical presentations in different pH conditions. In this paper we are reporting the reaction of tetramethyl-decaniobate ([(CH3)4N]6[Nb10O28]) with alkaline carbonates to observe the periodic trend of alkaline ions interacting with the...
The immobilization of chelators to solid supports has recently gained renewed interest due to the increasing biomedical and environmental applications made possible by these molecules’ ability to bind Fe(III) and other metal ions. The uses of immobilized chelators have expanded to include the treatment of metal overload in serum, the...
There have been many attempts to characterize and mimic natural fluid-based adhesive systems. However, very few of these studies have examined surface or interfacial interactions between adhesive and substrate. Furthermore, until now no study has used a combination of surface analytical and kinematic techniques to determine the precise chemical mechanisms...
As nanoparticle (NP) research and development expands, the significance of NP biodistribution effects on toxicity increases. A reliable method for measuring NP biodistribution is critical. Hyperspectral Imaging (HSI) is capable of accurately quantitating NP biodistribution within embryonic zebrafish with incredibly high precision. Before HSI processing, the embryo must be sectioned...
Cells in three-dimensional (3D) environments exhibit very different biochemical and biophysical phenotypes compared to the behavior of cells in two-dimensional (2D) environments. As an important biomechanical measurement, 2D traction force microscopy can not be directly extended into 3D cases. In order to quantitatively characterize the contraction field, we have developed...
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. 7:1186. doi: 10.1039/
C5IB00013K
24. Hopwood D, Spiers EM, Ross PE, Anderson JT, McCullough JB, and
Inherent nanomaterial characteristics, composition,
surface chemistry, and primary particle size,
are known to impact particle stability, uptake, and
toxicity. Nanocomposites challenge our ability to predict
nanoparticle reactivity in biological systems if they
are composed of materials with contrasting relative
toxicities. We hypothesized that toxicity would be
dominated by the nanoparticle...
Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Heterogeneous catalysis modulates the rate and selectivity of reaction processes by
stabilizing a series of intermediate states on solid surfaces, facilitating the production
of many commodity chemicals modern society relies upon. Conventional, thermal
catalytic processes—conducted at elevated temperatures and pressures—source
thermal, mechanical, and chemical potential energy from carbon-hydrogen bonds—
combustion...
The discovery of new blue pigments is a field of great interest, as commercially available pigments present properties that make them undesirable such as poor sustainability, cost, and stability. By researching solid solutions with the melilite structure, we discovered a new solid solution Sr2Zn1-xNixGe2O7, with 0.1 ≤ x ≤ 0.6,...
Chemical synthesis of oligonucleotides is a widely used tool in the field of biochemistry.
Several methods for gene synthesis have been introduced in the growing area of genomics.
In this paper, a novel method of constructing dsDNA is proposed. Short (28-mer) oligo fragments
from a library were assembled through successive...
This manuscript describes the role of non-classical hydrogen bonds (NCHBs), specifically C–H···O interactions, in modern synthetic organic transformations. Our goal is to point out the seminal examples where C–H···O interactions have been invoked as a key stereocontrolling element and to provide predictive value in recognizing future and/or potential C–H···O interactions...
Medusahead [Taeniatherum caput-medusae (L.) Nevski], a non-native, winter-annual grass (Poaceae), has
invaded rangelands throughout the western USA. Medusahead is an aggressive competitor that crowds out native plants
and reduces forage for wildlife and livestock. Sulfometuron methyl is a sulfonylurea herbicide used to control medusahead,
but its effect on non-target native...
This dissertation presents a study of structure-property relationships within 3d/4d metal oxides containing precious metals through detailed structure refinements using high-resolution neutron and X-ray diffraction data along with exploration of the resultant properties.
Oxides of 4d or 5d transition metals tend to show new topological phases due to significant spin-orbit...
We present a new nitrogen isotope model incorporated into the three-dimensional ocean component of a global Earth System Climate Model designed for millennial timescale simulations. The model includes prognostic tracers for the stable nitrogen isotopes, ¹⁴N and ¹⁵N, in the nitrate (NO₃ˉ), phytoplankton, zooplankton, and detritus variables of the marine...
In this work, colloidal PbSe quantum dots (QDs) are shown to be synthesized in a controlled manner by changing the growth time and reaction temperature in a microwave synthesis method. It is explained why quantum dots make such a unique material to create electronic devices and the specific benefits that...
Photoactivated biomedical tools like fluorescent biosensors and optogenetic proteins have increased in popularity due to the precision targeting and activation used for in vivo applications. In nature, the initially discovered parent proteins exhibit properties such as fluorescence quantum yield (FQY), fluorescence color, and photoswitching dynamics that are unfavorable in mammalian...
The inverse electron demand Diels Alder reaction between tetrazines and strained alkenes is an exceptionally useful tool in functionalizing to biomolecules since it is orthogonal to the chemistry of most living systems and have exceptionally high rate constants. In particular reactions between strained trans-cyclooctenes (sTCO) and tetrazines can achieve second...
Neptunium, with its rich redox chemistry, has a special position in the chemistry of actinides. With a decades-long history of development of aqueous separation methods for used nuclear fuel (UNF), management of neptunium remains an unresolved issue because of its not clearly defined redox speciation. Neptunium is present in two,...
Copper and iron are essential micronutrients that are required by marine primary producers for a variety of metabolic processes. Over 99% of both copper and iron are bound within organic complexes in the marine environment, however the molecular identity of many of these complexes remains unknown. The speciation of these...
The continued development of organic semiconductor materials relies on an understanding of the relationship between optoelectronic properties, molecular structure, and molecular interaction. Several detailed studies of electronic properties in functionalized polyacene materials are presented. A computational model which allows the extraction of charge generation and transport properties from experimental data...
Whey protein’s potential for bioactivity is well documented, but there is disagreement on the extent to which it may modulate the immune system towards decreased inflammation. Decreased inflammation is generally perceived as a beneficial bioactivity in foods as excessive chronic inflammation is linked to morbidity and mortality.
This thesis first...
CisCis-Dichloroethylene (ciscis-DCE), 1,1,1-Trichloroethane (1,1,1-TCA), and 1,4-Dioxane (1,4-D) are chlorinated solvents used as solvents and degreasers in industrial cleaning agents that have become common groundwater contaminants. To develop an effective treatment method for these compounds, polyvinyl alcohol (PVA) and sodium alginate (SA) hydrogel beads were co-entrappcapsulated with Rhodococcus rhodochrous Strain ATCC...