Alzheimer’s Disease (AD) is an abnormal part of aging that mainly affects those over the age of 65. The current therapies are only FDA approved for mild to moderate AD symptoms. Cannabidiol (CBD) is a non-intoxicating constituent of Cannabis sativa that has been shown to have beneficial effects on cancer,...
There is a growing need for individualized instructional designs in 4-year institutions due to: 1) growing undergraduate enrollment trends across the U.S., 2) broader diversity in students backgrounds, and 3) the growing prevalence of asynchronous remote learning. With the growth in computer technology in education, tools such as adaptive intelligent...
Human-robot teams involve humans and robots collaborating to achieve tasks under various environmental conditions. Successful teaming requires robots to adapt autonomously in real-time to a human teammate's state. An important element of such adaptation is the ability for the robot to infer the tasks performed by their human teammates. Human-robot...
Aromatic hydrocarbons represent a large class of environmental contaminants that have a broad range of structures, physicochemical properties, and toxicities. Arising from the burning of organic matter, particularly fossil fuels, they are both widespread and abundant in all environmental compartments. Both monoaromatic hydrocarbons (BTEX) and polycyclic aromatic hydrocarbons (PAHs) are...
Cell signaling under external stimulation is a critical mechanism that governs many biological processes such as cell proliferation, cell migration, and cell apoptosis, etc. For multicellular organisms, the ability to synchronize heterogeneous individual cellular responses through intercellular communication is crucial to maintain normal functionality. However, even though the biological pathways...
This report includes information concerning experimental use of unregistered pesticides or unregistered uses of pesticides. Experimental results should not be interpreted as recommendations for use. Use of unregistered materials or use of any registered pesticides inconsistent with its label is against both Federal Law and State Law.
The seafood industry has a problem of underutilization of harvested and processed fish. Up to 60% of the weight of the fish is considered a byproduct that is typically made into fishmeal for livestock and aquaculture feed, a low-value and non-food grade product. Two species that make up major fisheries...
This thesis examines the impacts of the COVID-19 pandemic on farms in the Willamette Valley. Using semi-structured interviews, this study analyzes the economic and social challenges created by the pandemic and the adaptation strategies farmers employed to build resilience within the food system. This study found that the farmers experienced...
Background
Feline injection-site sarcoma (FISS) is a rare and aggressive tumor associated with vaccines, drug injections, and skin trauma in cats. The understanding of FISS remains limited, posing challenges in its diagnosis, treatment, and prevention. In this study, we analyzed the differential expression of miRNAs and their target genes in...
Toxin production by cyanobacterial harmful algal blooms (cyanoHABs) in freshwater systems has lasting ecological and human impacts. Nutrients, light availability, hydrology, and microbial community composition impact the frequency and intensity of toxic cyanoHABs. Climate change will exacerbate toxic cyanoHABs, making real time and predictive monitoring a vital tool for managing...
Oomycete and fungal pathogens threaten food, fiber, and forests around the world. With climate change, these pathogens are expected to emerge more frequently. Evolution can facilitate their emergence through mechanisms such as mutations that change or expand host range. Characterizing evolutionary mechanisms in plant pathogens will contribute to our ability...
The body of work aims to contribute to the area of Quantitative analysis in Environmental Sciences, and is focused on the microbiome. The underlying theme for the dissertation is methods and workflow. The unique bioinformatics workflow used for the analysis of genomic data was used to answer distinct and pressing...
Oxidative dysfunction can affect dairy animals during periods of heightened stress, particularly during the transition from pregnancy to lactation and during diseases, such as intramammary infection (IMI), and can contribute to increased inflammation, immune dysfunction, and cell death. As such, methods for ameliorating oxidative stress and restoring redox regulation may...
Authentication is a means of developing an electronic signature that works like a written signature. It assumes that your data is publicly known but nevertheless ensures that the message is not tampered with and that you have an audit trail.
This project discusses the techniques and concepts used to design...
There has been serious interest in hydrogen as a source of energy in the United States due to its capability of delivering a sustainable, carbon-free energy future. Currently, most hydrogen in the United States is produced via the steam methane reforming of natural gas, which converts methane to hydrogen through...
The European hazelnut (Corylus avellana L.) is a tree nut crop that is important in Oregon, which produces 99% of the United States’ hazelnuts but only 5% of the world’s supply. In order to maintain this market share, farmers in Oregon need cultivars that produce high quality nuts, mature early,...
Radio frequency (RF) sensing arises as a promising option for enabling the internet of things (IoT) applications that transform our life into a world of smart homes, smart cities, and smart industries. The innovation of IoT reveals the benefits of RF sensing across cost, pervasiveness, unobtrusiveness, and privacy. However, challenges...
At a time when environmental conditions are rapidly changing, understanding how thermal extremes impact wildlife is imperative to fully understanding the consequences of climate change in natural ecosystems. While many organisms are currently impacted by rapidly warming and more erratic environmental conditions, identifying and investigating model species whose life histories...
The focus of this thesis is to design, characterize, and apply novel computational methods and molecular systems to interrogate heterogeneous human gut microbiome-related phenomena. In Chapter 2, I design, implement, and characterize a method for embedding co-occurrence patterns derived from massive 16s amplicon datasets. I use this method to 1....
This dissertation presents novel, field-activated smart material systems for the actuation and control of autonomous robots. Smart materials, a type of material whose properties can be changed with an external stimuli, represent a promising direction to expand upon existing robotic control and actuation methods, particularly in the sub-fields of soft...
The bimolecular reaction of two carbenoid species resulting in the formation of a carbon-carbon double bond (pi-system), referred to herein as carbenoid eliminative cross-coupling (CEXC), involves a series of three fundamental steps: (i) ate-complex formation (transmetalation), (ii) 1,2-metalate rearrangement, and (iii) beta-elimination. All three steps are stereospecific and so the...
Pre-spawning mortality (PSM) presents a major problem for population recovery of spring Chinook salmon (Oncorhynchus tshawytscha) in the Willamette River basin. In certain reaches and years, PSM has exceeded 90%. Histology has been used as the primary diagnostic method to investigate PSM in the Chinook Salmon, and a collection of...
Metallic glasses (MGs), also called amorphous metals, are metals or metallic alloys trapped in a disordered glassy state. Their amorphous nature and absence of features such as crystal lattices and defects (dislocations, grain boundaries etc.) endows them with a host of properties that far surpass those of common crystalline materials....
This project will act as a resource in secondary schools and workplaces to help facilitate discussion of discrimination and racially motivated crimes against people in the AAPI community. Decades of oppression have led us to the current oppression of Asian Americans, notably showcased during the COVID-19 pandemic. This project highlights...
Artificial collectives are useful for accomplishing tasks that require teamwork from multiple simple robots. Multiple robot and collective testbeds have been developed, yet none stay committed to leverage the local interactions, group size, and imperfect information assumptions that strengthen biological collectives. A review of the collective and multiple robot literature,...
Electrodeposition is a versatile polymer deposition technique to create nano-microscale materials using an electrical field generated from a charged droplet of solution and a grounded collector. Electrospinning or electrospraying can occur during electrodeposition, leading to the creation of nanofibers or bead-like materials depending on the process parameters. Photopolymerization of the...
Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Ultrafast spectroscopy has recently gained momentum as a powerful, noninvasive characterization toolset capable of studying a diverse array of samples with applications in chemistry, physics, biology, engineering, and more. Two popular ultrafast spectroscopic techniques include femtosecond transient absorption (fs-TA) and femtosecond stimulated Raman spectroscopy (FSRS). The latter of these techniques...
Managers of forest and plantation ecosystems are encountering growing problems involving plant pathogens and the expanding geographic ranges of these pathogens. Historically unexposed stands are exceptionally vulnerable when a non-native pathogen is introduced because these pathogens can cause devastating disease in a host population that lacks co-evolved resistance mechanisms. One...
In recent years, RF (Radio Frequency) device fingerprinting using deep learning has emerged as a method of identifying devices solely by their RF transmissions. Conventional approaches to this type of device fingerprinting are not portable to different domains. That is, if a model for this purpose is trained on data...
Oxides are a versatile class of materials with a wide range of electronic, optical, and magnetic properties. This makes them ideal for use in a multitude of functional devices for oxide electronics, electrochemical conversion, and storage. The overall performance of these devices is governed by atomic scale charge and mass...
Pesticides benefit agriculture by increasing crop yield, quality, and security. However, pesticides may inadvertently harm bees, which are valuable as pollinators. Thus, candidate pesticides in development pipelines must be assessed for toxicity to bees.
Leveraging a data set of 382 molecules with toxicity labels from honey bee exposure experiments, we...
Ultrafast spectroscopy can exploit the structure-function relationship of chemical- and biological-based systems. More specifically, femtosecond stimulated Raman spectroscopy (FSRS) provides ground- and excited-state vibrational information with simultaneously high spectral (spatial) and temporal resolutions. The electronic counterpart, femtosecond transient absorption (fs-TA), complements FSRS data analysis as part of a comprehensive approach...
The natural production of methane via anaerobic digestion (AD) is facilitated by a complex community of microorganisms, primarily bacteria and archaea, referred to as the AD microbiome. AD is growing in prominence as a solution to the disposal of food waste, sewage sludge, and the organic fraction of municipal solid...
Most marine fishes experience high rates of mortality during their early life history stages with far reaching consequences for adult population dynamics. Within a few weeks of hatching, relatively small changes in larval growth and mortality rates can lead to orders of magnitude variability in year-class strength. Growth and survival...
The continuous development of higher performing battery materials has emerged in parallel with the development of new manufacturing processes. Nanomaterials are one solution to addressing the cycling and performance challenges that limit existing battery cells. However, many of the methods used today for nanomaterial synthesis are high temperature batch methods...
Desalination stands for removing salt from saline water, and produce freshwater. Desalination technologies have been envisioned as a potential solution for freshwater production from oceans as an immense source of water acquiring 97% earth’s water, and 75% of earth’s surface. However, one third of world’s population face water scarcity every...
Melanocytes are dendritic, pigment-producing cells located in the skin and are responsible for its protection against the deleterious effects of solar ultraviolet radiation (UVR), which include DNA damage and elevated reactive oxygen species (ROS). They do so by synthesizing photoprotective melanin pigments and distributing them to adjacent skin cells (e.g.,...
Animals aggregate and interact in nonuniform and nonrandom patterns, which lead to group level characteristics that have important evolutionary and ecological consequences. Network analysis provides a useful conceptual framework for linking animal interactions at all scales from dyads to communities, to populations and ecosystems. Despite exciting theoretical and applied advances...
The ability to extract uncertainties from predictions is crucial for the adoption of deep learning systems to safety-critical applications. Uncertainty estimates can be used as a failure signal, which is necessary for automating complex tasks where safety is a concern. Furthermore, current deep learning systems do not provide uncertainty estimates,...
Coral reef ecosystems continue to be significantly altered by disease epizootics, but why some host populations remain resistant while others succumb to outbreaks remains unknown. Research across diverse animal and plant host systems has revealed that disease severity is strongly influenced by host genetics and by environmental influences on both...
Ph.D. candidate Qi Wei's thesis consists of two projects: Chemotherapy Project: a study based on the research paper "Predicting chemotherapy response of various cancer types using a variational auto-encoder approach" submitted to the bioRxiv preprint archive and accepted by the BMC bioinformatics; and Wound Monitor Project: implementing and assessing analytics...
The past decade of research has potentiated a revolution in our understanding of mammalian health and evolution by revealing that the gut microbiome plays a central role in mammalian physiology. Our ability to unlock this potential hinges upon the identification of specific groups of gut microbes that elicit effects on...
Magneto- and chemostratigraphic correlation underpins much of our understanding of Earth history, yet typical correlation techniques are neither quantitative nor objective. Within this dissertation, I detail my efforts to develop and apply dynamic programming-based algorithms that accomplish optimal and reproducible stratigraphic alignment. I apply these algorithms to three geologic intervals:...
In recent years, the research community's interest in fully integrated mm-Wave wireless communication systems has increased significantly. With the standards for 5G NR now in place, the focus has shifted to actual deployment. Mm-Wave systems provide wider bandwidths, higher capacity, and lower latency than existing systems such as 4G. Higher...