Propionic acid, live Propionibacterium shermanii, and
Dimethyl Fumarate (DMF) were tested for their stimulatory or
inhibitory efects on yeast, bacteria, and molds. The amount
of propionic acid required for inhibition of molds was
strain specific and equal to or less than that required for
inhibition of the yeasts. Live P....
Four different treatments of acetaminophen were administered to
eight healthy volunteers in multiple doses (five doses). Saliva
acetaminophen concentration-time profiles were determined. Non-compartmental
pharmacokinetic parameters for the first and last dose
were calculated and compared to determine whether acetaminophen
exhibited linear or dose dependent pharmacokinetics. Dose corrected
area under the...
Inhaled and intranasal corticosteroids (ICS and INS) are among the mainstays of the treatment for asthma and allergic rhinitis, respectively, and also carry the potential to suppress the hypothalamic–pituitary–adrenal (HPA) axis. Several important factors affect the interpretability of trials investigating the impact of ICS and INS on the HPA axis....
Development of a novel, useful, orally administered dosage form
providing controlled, sustained release of an active ingredient was desired.
Film layers of Aquacoat and Eudragit L-30D (commercially available
coating materials) were applied to acetaminophen cores. Amount of coating
material, number of polymer layers, and order of application were varied.
In...
Acetaminophen has been safely used for analgesia for many years.
Literature suggests that a plasma acetaminophen level of 5μg/ml is necessary to
maintain analgesic relief in humans. Current dosing regiments are inconvenient (every
4-6 hours) and do not maintain this minimum plasma level. Simulations were
conducted to examine various doses...
This dissertation describes formulation of a gastric retention device (GRD) and sustained release (SR) hydrochlorothiazide beads at Oregon State University. Formulation condition and amounts of excipients had significant influence on characteristic of the GRD. The GRD containing SR hydrochlorothiazide beads was employed to assess bioavailability/bioequivalency study in healthy subjects. An...
Internally-pH-controlled, phosphate containing and non-phosphate
containing Italian bulk starter media were compared to
reconstituted nonfat dry milk and commercial bulk starter media
for their ability to support the growth and activities of
commercially frozen thermophilic lactic acid cultures. Cultures
grown in internally-pH-controlled media demonstrated superior
acid-production capability. The cheese made...
Excess fatty acids and sterols are stored as triacylglycerols and sterol esters in
specialized cellular organelles, called lipid droplets. Understanding what determines the cellular
amount of neutral lipids and their packaging into lipid droplets is of fundamental and
applied interest. Using two species of fission yeast, we show that cycling...