Electrochemical sensing provides a quantitative alternative to colorimetric reactions within paper-based devices. The paper-based devices were fabricated by screen printing the conductive and reference inks onto porous substrates that were evaluated using cyclic voltammetry. Devices were evaluated based on the magnitude of the average anodic peak height, which correlates with...
Diatoms are single celled eukaryotic microalgae that self-assemble complex SiO₂
nanostructures by sillafin proteins within their cell wall. There has been increasing
interest in mimicking the diatom’s silica self-assembly process for fabricating metal
oxide nanoparticles, namely germanium dioxide (GeO₂). GeO₂ has a higher refractive
index than silica, enabling it to...
Surface-associated thrombosis is a critical concern in medical device development. Current extracorporeal circulation units require systemic anticoagulation to avoid thrombosis, which can cause adverse effects such as thrombocytopenia, hypertriglyceridemia, and hyperkalemia. To address this issue, we combine the technology of polydopamine (PDA) functionalization with slippery liquid infused porous surfaces (SLIPS)....
Metamix is a mixture of botanical compounds that promote healing and prevent infection for burns and diabetic ulcers. In this thesis, metamix was incorporated into 1.75 weight percent gellan gum hydrogels as a drug delivery method for burned skin. The ideal concentration of metamix was 25% by solution volume for...
Electroanalytical techniques allow scientists and engineers to characterize bulk solutions as well as interfaces. Potentiostats are commonly used by researchers in a variety of disciplines to analyze the chemistry which occurs at a working electrode surface. Advancements in microelectronics and the proliferation of open-source designs have allowed researchers to construct...
Glioblastoma multiforme is the most common primary brain tumor in adults ages 45-70, with over 12,120 new cases in the U.S. predicted for 2016 alone. Glioblastoma is also one of the most difficult cancers to treat because the tumor cells tend to invade into the surrounding healthy tissue, making it...
Glioblastoma multiforme is the most common primary brain tumor in adults ages 45-70, with over 12,120 new cases in the U.S. predicted for 2016 alone. Glioblastoma is also one of the most difficult cancers to treat because the tumor cells tend to invade into the surrounding healthy tissue, making it...
Rapid and effective treatment of burn injuries is critical to prevent long term damage. Besides the pain associated with the burn injury due to damage and death of surrounding tissue and cells, there is a large risk for complications, particularly infection, following a burn injury. To address these risks, Meta...
Nowadays, woody biomass is becoming increasingly significant because of its renewability and biodegradability. Lots of opportunities have been found to use excessive biological resources to derive products as diverse as fuels, heat, electricity, chemicals, food, clothing, paper, and much more. As such, biomass plays an important role in meeting demands...
Essential oils have numerous chemical and therapeutic applications. Some oil extraction methods, including steam distillation, require a large energy input. An alternative technique with a lower energy demand is the extraction of oils using supercritical liquid carbon dioxide (CO2), which extracts essential oils with minimal environmental impact. While this often...
The nature of engineering work requires that ethical considerations are taken into account while making decisions surrounding topics such as technology, equal distribution of cost benefits, and consumer risk. In order for engineers to make ethical decisions in their careers, it is helpful if their engineering education provided them with...
Sepsis is a blood infection that is caused by circulating bacteria cells and cell fragments, which contain immunogenic lipopolysaccharides (LPS) or endotoxin. The circulating endotoxin results in a severe dysregulation of the inflammatory response that ultimately leads to organ failure. One promising treatment method is removal of endotoxin by passing...
A common issue with extracorporeal medical devices is blood clotting due to bio-incompatibility. Systemic anticoagulants are often prescribed to mitigate the coagulation issues. However, such drugs can lead to further complications, for example hemorrhaging. One solution to improve the hemocompatibility of blood-contacting medical devices are biomaterials, such as slippery liquid...
This study is believed to be the first of its kind to characterize culturable fungal endophytes from the wood of Populus trichocarpa, and to examine the potential of inducible resistance and secondary chemistry as specific host factors that shape fungal endophytic communities in wood. To do so, more than seventy...
Platelet activation uses a complex set of pathways to respond to vascular injury during hemostasis. However, thrombosis relies on the same set of pathways. Antiplatelet therapies used to prevent thrombotic events often target the P2Y₁₂ platelet receptor for inhibition but can result in bleeding diathesis or in abnormally high ADP...
When vessel walls within the vasculature are damaged, exposed extracellular
matrix (ECM) proteins trigger a series of events that lead to the formation of a
hemostatic plug (Andrews et al. 2004, Furie et al. 2008, Watson 2009). Thrombus
formation requires an orchestrated series of receptor-mediated events facilitating platelet
recruitment, platelet...
According to the Center for Disease Control and Prevention (CDC), in 2015 10.4 million people worldwide became infected with tuberculosis (TB) with 1.8 million TB related deaths. Tuberculosis is a bacterial infectious disease caused by Mycobacterium tuberculosis, a slow growing yet highly infectious bacterium. Among the first line of treatments...
Antimicrobial coatings used to reduce the risk of infection caused by tissue-contacting medical devices must address specific biocompatibility requirements including prevention of thrombosis and rise of bacterial resistance. An antimicrobial-loaded poly(ethylene-oxide) (PEO) coating has been tentatively shown to be non-fouling with sustained antimicrobial activity. However, the presence of the antimicrobial,...
Polyfunctional thiols are sulfur containing compounds that are important to the flavor and aroma profile of some foods and beverages. S. Cerevisiae has been shown in wine yeast that it is capable of producing these thiols to create a fruity aroma and flavor profile. IRC7, a gene that codes the...
The majority of people suffer from back pain at some point in their lives. Back pain is the leading cause of disability globally, ahead of 290 other conditions1. Over one million people in the United States receive spine surgery annually2. This thesis looked at five standard surgical procedures performed on...
Successful cryopreservation of bone marrow in situ within vertebral bodies offers an opportunity for quick and convenient storage of a significant quantity of bone marrow stem cells, including hematopoietic- and mesenchymal-type stem cells. However, cryopreservation of more complex large tissues and organs, such as the vertebral body (VB), remains problematic....
Unpaved roads are sources of chronic sediment in forested watersheds. Bare soil on roads is exposed to erosion from rainfall and runoff Published research on sediment production from forest roads focuses primarily on road characteristics. Since water drives the mechanics of sediment transport, hydrologic variables should correlate with sediment production....
Paper microfluidic devices are capable of processing fluids using capillary flow in materials that are lower cost than the standard materials used in microfluidics. Due to the low cost of their fabrication and minimal requirements for instrumentation, paper microfluidic devices are ideal for use in low-resource settings. They have the...
The use of ureolytic bacteria for the remediation of contaminated groundwater aquifers by inducing calcium carbonate precipitation is being studied in order to establish a better understanding of the modeling and prediction of how the bacteria will act in situ. This research has pursued the use of various ureolytic bacteria...
The improvement of coupled tendon transfer surgeries through the insertion of an adaptive engineering mechanism was explored using biomechanical simulations performed in OpenSim. Tendon transfer surgeries are commonly performed on the upper extremity to restore hand function. A conventional 4-tailed tendon transfer procedure model and a modified 4-tailed procedure model...
Surface patterning of bacterial biofilm provides an opportunity to understand the microbial metabolic exchange between bacterial species. By using various techniques, one can put different bacterial species in close proximity and study their interaction by using various assay kits and analytical techniques. In this study, surface patterning of Pseudomonas aeruginosa...
Cytoplasmic dynein is a motor protein complex found in eukaryotes that is essential to many cellular processes. With dynein being involved in mitosis, axonal transport and organelle transport, disruption of dynein function can lead to neurodegeneration and other diseases. The main function of dynein is transportation of cargo through the...
Loss of a limb can severely impact everyday way of life. Prosthetics provide a way to return functionality to the user and improve quality of life. However, most prosthetic systems currently available in the market lack sensory feedback making them comparatively more difficult to use resulting in prosthetic abandonment. Therefore,...
Infections in hospitals account for over 100,000 deaths per year. These infections occur at the
hospital from complications following bacterial adhesion to intravenous catheters, coronary
stents and other implanted devices. Another common problem is protein adsorption to the
surface of the device and subsequent blood clotting. Methods for combating these...
The matrisome is an ensemble of genes that are highly relevant for characterizing the behavior of the extracellular matrix (ECM) during the onset and progression of many diseases. Recent advances in the definition of the matrisome, such as The Matrisome Project, have been instrumental in making more advanced resources available...
The Jovanovic lab at Oregon State University (OSU) is developing iCore, a versatile blood processing platform which leverages microfluidic process intensification via increased mass transfer efficiency and decreased device footprint with the goal of creating a portable, wearable device. One application of iCore is for the treatment of hyperferremia resulting...
Our society today is heavily dependent on fossil fuels such as coal and oil. However, growing environmental concerns and future fossil fuel supplies have led to interests in alternative fuels. Dimethyl Ether (DME) is an inexpensive, clean-burning, non-toxic, and potentially renewable fuel, making it a suitable choice as an alternative...
An understanding of oppression and privilege would improve engineering climates and encourage individuals with marginalized identities to stay engaged in engineering spaces. Currently there are quantitative tools to assess cultural competencies, but none that measure understandings of power relationships. This project aims to create a qualitative assessment instrument to measure...
Ammonia oxidizing bacteria, including Nitrosomonas europaea, are inhibited by aromatic hydrocarbons which can be found in wastewater treatment plants. In recent studies, changes have been observed in N. europaea cell size upon exposure to benzene, but not toluene. Additionally, NE 1545, a gene proposed to be involved in fatty acid...
Sepsis, caused by bacterial release of endotoxin, is a serious blood infection that causes uncontrolled systemic immune response. In North America alone, sepsis kills between 220,000 and 380,000 people each year, more than prostate cancer, breast cancer, and HIV/AIDS combined. Sepsis treatment is complicated and often requires prolonged hospital stays,...
Monitoring the concentration of phenolic compounds is important for environmental regulation, health diagnostics, and bioenergy fermentation. Vanillin is a phenol compound used as a food flavoring that can cause allergies and inhibits biofuel production. The phenol m-cresol is a toxic compound that is regulated in the environment and in human...
There are at least fifteen types of upper extremity tendon transfer procedures for combined peripheral nerve injuries that involve re-routing a single donor muscle to multiple recipient tendons. As a result, force and movement across finger joints become coupled, resulting in limited grasping abilities. Quantification and modeling of the donor...
Neonatal jaundice secondary to hyperbilirubinemia occurs in 60% of all term newborns and nearly all preterm newborns in the US. Severe cases of this may lead to chronic encephalopathy, neurologic deficits, and, in some cases, death. Intensive blue light phototherapy involves irradiation of a patient with high intensity light and...
The consumption of alcohol has been shown to have effects on health that are both harmful and
therapeutic, depending on the amount that is consumed. Alcohol’s effects can be damaging to the body in excess but, in moderation, can act as a protectant against certain conditions. The two studies discussed...
Throughout a large portion of our planet, malaria has been nearly eradicated or reduced to levels that are highly manageable, and many countries possess the means to effectively treat the disease. However, many areas of the world, such as Sub-Saharan Africa and Southeast Asia, are still heavily burdened by malaria....
As access to potable water grows scarce, there is an increasing reliance on alternative drinking water sources, namely groundwater (WHO, 2018). Chlorinated solvents, such as 1,1,1-trichloroethane (TCA) and 1,2-cis-Dichloroethene (cisDCE) are some of the most ubiquitous groundwater contaminants spread throughout the US. 1,4-dioxane (1,4D) was used primarily in the late...
The ability of nanoparticles (NPs) to induce oxidative stress on organisms has been linked to NP cytotoxicity and genotoxicity for a variety of organisms. One proposed mechanism of this increased oxidative stress is the ability of NPs to generate reactive oxygen species (ROS). Due to the dynamic nature and small...
Sepsis is a life-threatening blood infection which leads to an uncontrolled systemic inflammatory state. In North America alone, sepsis annually afflicts approximately 750,000 individuals and kills 38-50% of these (more than HIV/AIDS, breast cancer, and colon cancer combined). Current treatment involves administration of IV fluids, antibiotics and hemoperfusion, requiring prolonged...
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23. Mean diameter of WLBU2 kill zones against E. coli and P. pentosaceus. A small effect of
Currently, wax printing is limited to materials that can be processed by a wax printer. Wax transfer printing is a method that allows previously unusable materials to be patterned with wax via an intermediate template. Millipore cellulose, a material too thick to be processed by a wax printer, was patterned...
Xanthan gum, a naturally produced polysaccharide, is biocompatible, and it is commonly used as a food additive. When combined with trivalent ions, such as chromium (III), a gel can form. Various concentrations of xanthan gum and chromium (III) nitrate were combined to evaluate the sol-gel transition of this system. Samples...
Nitrate (NO₃-) accumulation in water sources is a serious health and environmental concern. Common methods used to reduce NO₃- accumulation have one or more undesirable traits that limit their efficacy in large-scale decontamination. However, treatment of NO₃- electrochemically is a promising area of study because of the absence of toxic...
Technology is constantly co-evolving with science to produce simple and effective tools that address the needs of researchers. Cost and time effective point-of-care devices are valuable for sample collection and analysis, particularly in medicine and environmental health and safety. Digital microfluidic (DMF) technology provides a possible solution. This study explores...
The factors that cause abdominal aortic aneurysm rupture were investigated. Included
in this study were aneurysm volume, thrombus thickness, lumen area, thrombus area,
the average stress acting on the aorta, and the maximum stress on the aorta. The
geometric values were obtained by tracing a series of computerized axial tomography...
The development of simple, rapid, and sensitive methods for thiophenol detection is of great importance in various fields, including environmental monitoring and food quality. Here, we present a novel approach for the colorimetric detection of thiophenols using gold nanoparticles (AuNPs) as the sensing platform. AuNPs aggregate in the presence of...
Presented here is an investigation and comparison of two entrapment methods of algae. Conventional calcium alginate bead entrapment is compared to a recently described modified bead entrapment method, utilizing poly(ethylene glycol) and calcium alginate, which results in void or capillary formation within the beads. It is shown that algal growth...
Bioprocessing design includes optimizing unit operations in a process in order to attain a desired amount of product. Process economics, safety, environmental impact, and product quality are considered. This study investigated which skills and conceptual knowledge related to bioprocessing design were most important for entry-level engineers in the bioprocessing industry....
Personal health monitoring tools, a subset of point-of care-diagnostics, enable more frequent testing of chronic health conditions outside of a clinic setting and can inform personalized therapy or support telehealth diagnostic capabilities. While there is evidence that regular monitoring of chronic conditions can lead to better health outcomes and lower...
Granulocytes are a class of white blood cells essential to immune function. Granulocyte transfusions hold promise to treat many conditions, but the short-shelf life of granulocytes makes transfusions infeasible without a cell preservation method. The purpose of this study was to investigate the potential for cryopreservation of granulocytes using 30%...
Sepsis is a blood infection caused by circulating pathogens and cell wall fragments that affects over 1 million patients per year in the United States. When bacterial cell membranes are lysed by antibiotics, cell wall fragments containing lipopolysaccharides (LPS) are released. As a result, the capture of LPS is critical...
Physical activity is associated with significant health benefits. These benefits include lower risk of cardiac disease, depression, and obesity. Physical activity in young children, 1-5 years old, is extremely important as children need to develop foundations of physical activity in order promote lower risk for diseases. A study with nine...
Hyperuricemia is the condition of excessive presence of plasma uric acid ≥ 6 mg/dl. Conventional clinical/hospital urate-lowering treatment includes the administration of non-steroid anti-inflammatory drugs or xanthine oxidase inhibitors. Numerous drawbacks can be observed from these conventional treatments. In patients with refractory gout symptoms and tumor lysis syndrome, recombinant uricase...
This work describes a method for incorporating patient data into a nutrient transport model of the intervertebral disc.This data was collected using MRI diffusion weighted imaging (DWI), and was converted into an apparent diffusion coefficient map (ADC map). This map was used to define the diffusion behavior of water within...
Social networking is the concept that personal connections can form a large web of people and institutions that are essential in an individual’s realization of a goal. Social networking plays an important role in almost every business venture. This has proved to be especially true in the story of Aegir...
Despite the many advances in biotechnology and biomedical engineering, the need for long term organ and tissue storage remains among the unsolved problems in the field. Researchers are investigating several possible solutions to the issue that aim to maintain the function and integrity of the biological tissues during storage and...
Ceratonova shasta is a myxozoan fish parasite that impacts hatchery and wild populations of salmon and trout in the Pacific Northwest. Levels of the parasite in river water can be effectively monitored through direct filtration of parasite spores from water, extraction of total "environmental DNA" (eDNA), then quantitative polymerase chain...
Multicellular coordination in response to environmental stimuli is essential in biology, and this coordination is often achieved by a division of labor to establish leaders and followers in a cell population. This is called emergent leadership, but how a cell adopts its role and effectively exchanges information with peers is...
Cystic fibrosis is an inherited genetic disease caused by a single gene mutation in the CFTR protein. Affecting 70,000 people worldwide, this disease is debilitating to patients, resulting in persistent lung infections and decreased quality of life. Due to the various mutation types, there is not currently a single drug...
Advancements in the field of medical and computer technology promise a new age of human enhancement technology (HET). These technologies may be aptly applied to existing Assistive Technology (AT), which was created to ameliorate disability, moving one up the spectrum of ability. This study aimed to determine how these technologies...
Orthopaedic soft tissue degenerative diseases significantly affect the population, especially as it ages. Degeneration is characterized by a progressive loss of extracellular matrix (ECM) components necessary for the proper functioning of the tissues and joints, eventually leading to pain and dysfunction. In humans, the intervertebral disc (IVD) and tendon are...
The human intervertebral disc is a deceptively simple structure which plays an essential role in human movement. Even slight changes to the disc microenvironment can have far reaching consequences, particularly when these changes result in disc degeneration and herniation. Degeneration is increasingly tied to lower back pain; better understanding this...
Artificial lipid bilayer technologies are effective models for studying cell membrane properties. Droplet bilayers rely on microfluidics and provide advantages over other bilayer methods due to their compatibility with automated development systems that increase yield while minimizing cost. This paper describes the implementation of bilayer technologies using membrane protein channels...
The purpose of this project is to characterize mixing effects of the Beta 2 tool that is under development by the Hewlett Packard Pinot team. By optimization of a stage oscillation process, the undesirable effects of a locally high concentrated drug elution within a well plate can be alleviated. This...
The ethics of implant technology is a wide-ranging topic in the field of bioethics. This paper intends to add to the ethical discourse of implant technology by addressing a new class of implants applicable to orthopedic surgery. These new implants are engineered mechanisms that attach muscles to tendons and bones...
Incoming and graduating engineering students in the School of Chemical, Biological, and Environmental Engineering at Oregon State University were surveyed in order to assess awareness and integration of social responsibilities into their emerging professional persona and how those views are informed by program and faculty interactions. Preliminary analysis of responses...
Back pain is the leading cause of disability worldwide, entailing a significant socioeconomic impact. A primary source of back pain can be attributed to intervertebral disc (IVD) degeneration allowing nerve ingrowth, facet joint arthritis, disc bulging, and osteophyte formations that press on nearby nerve roots or the spinal cord. While...
Regular ankle taping is commonly used to prevent ankle sprains, but the effects of its
long-term use are not fully understood. This study examined the effects of ankle
taping on balance in athletes who regularly tape their ankles versus those who do not.
Fourteen collegiate gymnasts’ ability to balance on...
Shoulder injuries, especially those caused by rotator cuff tears, are a pervasive problem in human and canine patients. The ability to quickly and accurately diagnose rotator cuff tears is important for early and targeted treatment. Prior clinical work has demonstrated that ultrasound and magnetic resonance imaging effectively diagnose these tears....
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Morgan Giers
Shoulder injuries, especially those caused by rotator cuff tears, are a
Plastic pollution is an ever-increasing environmental threat. As large-scale plastics break down to form nanoscale plastics, it is essential to investigate their effects on freshwater ecosystems. With many plastic nanoparticle (NP) studies favoring the effects of common polystyrene (PS) plastics, a gap is formed for other common plastic types like...
Ocean deoxygenation is predicted to increase in severity over the next few decades, posing a threat to marine life and fishing economies. Improved predictions of ocean deoxygenation depend on a better understanding of the biogeochemical mechanisms that underly this process. Within the realm of biogeochemical mechanisms, this project specifically investigated...
Due to the many advances in the areas of biotechnology and medicine, the need for long-
term storage and stabilization of biological materials is rapidly increasing. The field of
biopreservation is attempting to address these issues by finding ways to maintain the integrity and
functionality of proteins, cells, and organs...
The action of pendant, polyethylene oxide (PEO) brush layers as nonfouling coatings for
biomedical materials is well understood. However progress toward clinical application of stable, high density PEO coatings has historically been impeded by the lack of cost effective, noninvasive methods for their preparation. Triblock polymers featuring a hydrophobic, polypropylene...
Effective surface coatings for tissue-contacting medical devices should prevent both biofilm formation and infection. One method to achieve this aim is protein repellant polyethylene oxide (PEO) brush coatings loaded with antimicrobials. Previous research has demonstrated that the antimicrobial nisin adsorbs to PEO brush layers in multi-layer amounts and suggests that...
Triple-negative breast cancer (TNBC) is a particularly aggressive molecular subtype of malignant cells that tends to proliferate quickly and is commonly resistant to traditional chemotherapy leading to relapses in prognosis more frequently than other forms of breast cancer (BCa) [1][2][3]. Current treatment options include surgical resection of cancerous tissue and...
The Arabidopsis thaliana developmental promoters of WUSCHEL (WUS) and COLD SHOCK DOMAIN PROTEIN 3 (CSP3) were tested for their suitability as potential control elements for the Cre-Lox recombination system in poplar cells. To remove the integrated transgene after CRISPR machinery has modified the genome, timely control of Cre is required....
This study examines issues related to prescription drug abuse among 12 – 17 year olds in the United States; namely, the physiological effects of prescription medications, current treatments, and prevention methods. The following research questions are addressed: 1) What factors influence and promote the growing prevalence of prescription drug abuse...
The human intervertebral disc (IVD) provides support for the vertebral bodies, allowing for movement and load bearing. The IVD can degenerate with age or injury, impeding function and causing chronic pain. Despite disc degeneration affecting over 90% of adults over age 50, and back pain being the leading global cause...
The pulse-coupled oscillator model is widely used to simulate the dynamics of neural systems. For networks with particular internal (Mirollo-Strogatz) dynamics, I will define three broad patterns of collective behaviors found in literature in terms of inter-spike interval (ISI) statistics. These patterns are i) temporally-regular, characterized by all oscillators in...
Tendinopathy is characterized by injured or inflamed tendons and can be caused by long durations of strain or excessive tension being applied. Current treatments for tendinopathy may include physical therapy and pain management. However, these methods may not heal the tendon or restore it to its original healthy state. New...
Anammox (Anaerobic Ammonium Oxidation) is a significant biogeochemical process carried out by certain bacteria, generally referred to as anammox bacteria. These bacteria have the ability to anaerobically oxidize ammonium (NH4+) with nitrite (NO2-) to form nitrogen gas (N2) without an organic carbon source. While anammox bacteria are found in a...
Plastics have become an essential part of everyone lives, found in almost every product made today. Tires only make up a fraction of these products but as their use increasing so does the microplastics that flake off. Many studies have evaluated the toxic effects of tire particles on aquatic environments...
There is no standardized method for culture of intervertebral disc (IVD) cells when monitoring metabolic processes. We hypothesize that the metabolic rates of cells that are crucial to experiment designs depend on the cell culture method used. The glycolytic pathway and the tricarboxylic acid (TCA) cycle are the pathways through...
Degeneration of the intervertebral disc (IVD) is a phenomenon that has yet to be adequately addressed. Treatment options remain limited and incomplete. The ability to effectively cryopreserve IVDs would allow for better allograft transplantations and storage of samples for research purposes. This study aimed to assess how cryopreservation with different...
Eukaryotic cells have developed elaborate biochemical processes to counteract oxidative stress, electrophiles, or carcinogens due to environmental insults. One of these important cellular defense mechanisms is mediated by the transcription factor Nrf2 that have been shown to have decrease activity with age. While the process of which Nrf2 is involved...
Invasive breast cancer affects 1 in 8 women during their lifetime. Current cancer research uses 2-D cell culturing, which does not accurately represent tumor behavior. In comparison to tumors, cells grown using 2-D cell culturing have different proliferation and diffusion rates, cell shapes, and gene expression. To improve in vitro...
The forest products industry relies on the production of high-quality wood to satisfy consumer requirements. Improving wood quality requires an effective and inexpensive technique for measuring critical properties such as density and microfibril angle. An emerging technology known as near-infrared hyperspectral imaging (NIR HSI) essentially captures surface images of samples...
Ligaments serve to control the movements of bones and joints within the body. Viscoelastic properties, such as hysteresis, allow them to perform their functions; however, these properties may change following injury. Understanding alterations in viscoelastic properties may be useful in diagnosing, tracking, and determining treatment effectiveness in Chronic Ankle Instability...
Interventions for young children with Autism Spectrum Disorder (ASD) focus on core impairments in social communication skills, yet studies have shown a relationship between social and motor skill deficits in children with ASD. The purpose of this study is to further examine individual levels of gross and fine motor skills...
Metal-organic frameworks (MOFs) have emerged as promising candidates in novel cancer therapies due to their unique properties, including high surface area, tunable crystal size, and exposed metal ion active sites for catalysis. The MOF NH2-MIL-88B has shown potential use in cancer theranostics. Its open metal active sites catalyze the reduction...
Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...
Hemodynamic forces regulate vascular homeostasis and arterial structure through mechanical stimuli by a process called mechanotransduction. Cellular response to mechanical forces involves coordination between cell surface receptors and intracellular signaling pathways. While previous work has focused on the role of integrin receptors in mechanotransduction, little is known about the role...